ChemicalBook CAS DataBase List 13721-39-6

13721-39-6

Name	Sodium orthovanadate
CAS	13721-39-6
EINECS(EC#)	237-287-9
Molecular Formula	Na3O4V
MDL Number	MFCD00003511
Molecular Weight	183.91
MOL File	13721-39-6.mol

Synonyms

DECAVANDATE SODIUM ORTHOVANADATE SODIUM ORTHOVANADATE(V) SODIUM O-VANADATE SODIUM VANADATE SODIUM VANADATE, ORTHO (beta-4)-vanadate(vo43-trisodium Sodiumorthovanadate,dodecahyd sodiumtetraoxovanadate(3-) sodiumvanadate(v)(na3vo4) sodiumvanadiumoxide(na3vo4) trisodium(t-4)-vanadate(vo4(3-) trisodium,(T-4)-Vanadate trisodiumorthovanadate trisodiumvanadate vanadic(ii)acid,trisodiumsalt Vanadicacidtrisodiumsalt Sodium orthovanadate dodecahydrate sodium tetraoxovanadate trisodium tetraoxovanadate

Chemical Properties

Appearance	white to off-white powder
Melting point	850-866 °C(lit.)
storage temp.	Sealed in dry,Room Temperature
solubility	H₂O: soluble
form	Solid
color	off-white
Stability:	Stable. Incompatible with strong oxidizing agents.
biological source	synthetic (organic)
Water Solubility	soluble
Exposure limits	NIOSH: Ceiling 0.05 mg/m3
InChI	InChI=1S/3Na.4O.V
InChIKey	HQHUIUQMQXUPHI-UHFFFAOYSA-N
SMILES	[V](=O)(O[Na])(O[Na])O[Na]
CAS DataBase Reference	13721-39-6(CAS DataBase Reference)
EPA Substance Registry System	13721-39-6(EPA Substance)

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302+H312+H332-H315-H319
Precautionary statements	P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338
Hazard Codes	Xn
Risk Statements	R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . less more
Safety Statements	S22:Do not breathe dust . S36:Wear suitable protective clothing . less more
RIDADR	UN3285
WGK Germany	3
RTECS	YW1120000
TSCA	Yes
HazardClass	6.1
PackingGroup	III
HS Code	28419030
Storage Class	13 - Non Combustible Solids
Hazard Classifications	Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2
Safety Profile	Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of VOx and NazO. See also VANADIUM COMPOUNDS. less more

Raw materials And Preparation Products

Hazard Information

Hazard

Poison by ingestion.

Chemical Properties

white to off-white powder

Uses

Sodium orthovanadate (Na₃VO₄) can be used as a metal precursor in the synthesis of:

Vanadium-MCM-48 (V-MCM-48) by anion-exchange method. V-MCM-48 is used as a catalyst in oxidation of styrene to benzaldehyde.
Nanorods of vanadium oxide particles by glycothermal method.
Yttrium vanadate (YVO₄) doped with colloidal europium.

Uses

Sodium orthovanadate is an alkaline phosphatase and (Na,K)-ATPase inhibitor with IC50 of 10 μM.

Uses

Sodium Orthovanadate is an inhibitor of several phosphatases and kinases. General inhibitor of tyrosine phosphatases, a large family of enzymes that catalyze the removal of phosphate groups from tyrosine residues.

Definition

ChEBI: Trisodium vanadate is an inorganic sodium salt of formula Na3VO4 containing the tetrahedral VO4(3-) It has a role as an EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor, a radiation protective agent, an apoptosis inducer and an antineoplastic agent. It contains a vanadate(3-).

Preparation

Sodium orthovanadate is produced by dissolving vanadium(V) oxide in a solution of sodium hydroxide:
V2O5 + 6 NaOH → 2 Na3VO4 + 3 H2O
The salt features tetrahedral VO3-4 anion centers linked to octahedral Na+ cation sites.

reaction suitability

reagent type: catalyst
core: vanadium

Biological Activity

Inhibitor of protein tyrosine phosphatases, alkaline phosphatases and ATPases.

Biochem/physiol Actions

Sodium orthovandate suppresses the activation of p53-mediated apoptosis triggered in response to radiation. It reduces the detrimental effects of hematopoietic syndrome, hematopoiesis and delayed genotoxic effects of induced by total body irradiation of mice.24 In combination with menadione, orthovandate prevents the migration of detached human glioma cells in response to anti-cancer drugs.25

storage

Store at RT

Material Safety Data Sheet(MSDS)

Spectrum Detail

Well-known Reagent Company Product Information

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