Uses
N-(3-Methylphenyl)-4-(2-pyridinyl)-1-piperidineacetamide-d7 Dihydrochloride is labelled N-(3-Methylphenyl)-4-(2-pyridinyl)-1-piperidineacetamide Dihydrochloride (M320725) which acts as a selective agonist against dopamine D4 receptors, which affect cognitive performance and activity.
Biological Activity
a 412997 dihydrochloride is a selective agonist of dopamine d4 receptor with ki values of 7.9 and 12.1 nm for human and rat d4 receptors, respectively [1].dopamine d4 receptor is a g protein-coupled receptor and is activated by dopamine. it plays an important role in cognition, parkinsons disease, addictive behaviors and so on.a 412997 dihydrochloride is a selective dopamine d4 receptor agonist. in calcium flux functional assays, a-412997 activated the rat dopamine d4 receptor with ec50 value and intrinsic activity of 28.4 nm and 0.83, respectively [1].in spontaneous hypertensive rat pups (shr pups), a 412997 significantly increased acquisition in the 5-trial repeated acquisition model. in the short-term social memory, a 412997 significantly shortened the second investigation time. in wistar rats and dawley rats, a 412997 (3 μm/kg, 10 μm/kg) increased locomotor activity [2]. in rats, a 412997 reduced non-rapid eye movement (nrem) sleep duration and increased waking duration. also, a 412997 reduced rapid eye movement (rem) sleep duration and delayed the onset of rem sleep [3].
References
[1]. moreland rb, patel m, hsieh gc, et al. a-412997 is a selective dopamine d4 receptor agonist in rats. pharmacol biochem behav, 2005, 82(1): 140-147.
[2]. browman ke, curzon p, pan jb, et al. a-412997, a selective dopamine d4 agonist, improves cognitive performance in rats. pharmacol biochem behav, 2005, 82(1): 148-155.
[3]. nakazawa s, nakamichi k, imai h, et al. effect of dopamine d4 receptor agonists on sleep architecture in rats. prog neuropsychopharmacol biol psychiatry, 2015, 63: 6-13.
