129029-23-8

Ocaperidone shows a potent occupation of 5HT₂ receptor via in vivo binding in the frontal cortex of rats with an ED₅₀ of 0.04 mg/kg, and 0.1 4-0.1 6 mg/kg for D₂ receptor in the striatum and the nucleus accumbens^[1]. Ocaperidone (R 79598) antagonizes dopamine D₂ and 5-HT₂, and shows a a partial generalization to buspirone with an ED₅₀ of 0.163 mg/kg^[3].