ChemicalBook CAS DataBase List 128446-36-6

128446-36-6

Name	beta-Cyclodextrin methyl ethers
CAS	128446-36-6
EINECS(EC#)	1308068-626-2
Molecular Formula	C54H94O35
MDL Number	MFCD00074980
Molecular Weight	1303.3
MOL File	128446-36-6.mol

Chemical Properties

Appearance	White powder
Melting point	180-182 °C(lit.)
alpha	+159°(25℃, c=1, H2O)
Fp	187 °C
storage temp.	room temp
solubility	H2O: soluble50mg/mL
form	powder
color	White to off-white
biological source	synthetic (organic)
Optical Rotation	[α]25/D +159°, c = 1 in H2O
Water Solubility	Soluble in water
Cosmetics Ingredients Functions	CHELATING
InChIKey	YZOUYRAONFXZSI-SBHWVFSVSA-N
SMILES	O1C2OC(C(OC3OC(C(OC4OC(C(OC5OC(C(OC6OC(C(OC7OC(C(OC8OC(C1C(C8OC)O)COC)C(C7OC)O)COC)C(C6OC)O)COC)C(C5OC)O)COC)C(C4OC)O)COC)C(C3OC)O)COC)C(C2OC)O)COC
LogP	-2.566 (est)
EPA Substance Registry System	.beta.-Cyclodextrin, methyl ethers(128446-36-6)
Absorption	≤0.10 at 350-600nm in solution at 10% ≤1.00 at 220-350nm in solution at 10%

Safety Data

Symbol(GHS)	GHS08
Signal word	Warning
Hazard statements	H317-H361
Precautionary statements	P201-P202-P261-P272-P280g-P302+P352-P308+P313-P363-P403-P501c
Safety Statements	22-24/25 less more
WGK Germany	3
TSCA	Yes
HS Code	35051000
Storage Class	11 - Combustible Solids

Hazard Information

Chemical Properties

White powder

Uses

substrate for laminarinase and other glucanases

Description

Methyl-β-cyclodextrin is a randomly methylated form of the cyclic oligosaccharide β-cyclodextrin (Item No. 23387). Methyl-β-cyclodextrin contains seven D-(+)-glucopyranose units that contain randomized hydrogen or methyl groups. Methyl-β-cyclodextrin has been used to improve the aqueous solubility of various compounds and to extract cholesterol from lipid membranes. Methyl-β-cyclodextrin (5 mM) reduces α-synuclein levels in the membrane and detergent-insoluble fractions from B103 neuroblastoma cells transfected with human α-synuclein. It also reduces α-synuclein levels in mouse brain in a transgenic model of α-synucleinopathy.

General Description

Methyl-β-cyclodextrin is a small cyclic heptasaccharide.

Biochem/physiol Actions

Methyl-β-cyclodextrin participates in increasing the permeability of cells. It also plays a role in depolymerizing the actin cytoskeleton in cells. Methyl-β-cyclodextrin is involved in attracting cholesterol from the plasma. It participates in activating extracellular receptor kinase in certain cells.

References

[1] MOJCA PODLESNIK BESENI?AR . Kinetics of cholesterol extraction from lipid membranes by methyl-β-cyclodextrin—A surface plasmon resonance approach[J]. Biochimica et biophysica acta. Biomembranes, 2008, 1778 1: Pages 175-184. DOI: 10.1016/j.bbamem.2007.09.022
[2] PAZIT BAR-ON. Effects of the cholesterol-lowering compound methyl-β-cyclodextrin in models of α-synucleinopathy[J]. Journal of Neurochemistry, 2006, 98 4: 1032-1045. DOI: 10.1111/j.1471-4159.2006.04017.x

Spectrum Detail

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