ChemicalBook CAS DataBase List 127317-03-7

127317-03-7

Name	H-HIS-SER-ASP-GLY-ILE-PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ALA-ALA-VAL-LEU-NH2
CAS	127317-03-7
Molecular Formula	C142H224N40O39S
MDL Number	MFCD00167418
Molecular Weight	3147.61
MOL File	127317-03-7.mol

Synonyms

ovine M-PACAP PACAP-27 PACAP 1-27 PACAP-27 (human PACAP (1-27) AMIDE Human PACAP-(1-27) PACAP 27 AMIDE, OVINE PACAP-27 (HUMAN, OVINE, RAT) powdered posterior pitultary HSDGIFTDSYSRYRKQMAVKKYLAAVL-NH2 PACAP (1-27), HUMAN, OVINE, RAT PACAP (1-27) (HUMAN, SHEEP, RAT) porcine rat) trifluoroacetate salt PACAP (1-27), AMIDE, HUMAN, OVINE, RAT ADENYLATE CYCLASE ACTIVATING PEPTIDE-27 PACAP27 (HUMAN, 1-27 AMIDE) (OVINE, RAT) PACAP-27 (HUMAN, MOUSE, OVINE, PORCINE, RAT) pituitary adenylate cyclase activating*polypeptid ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE-27 OVINE PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE [ARG14,20,21, LEU16] PACAP (1-27), HUMAN, OVINE, RAT PACAP 27 Amide, Ovine - CAS 127317-03-7 - Calbiochem PITUITARY ADENYLATE CYCLASE-ACTIVATING PEPTIDE (1-27) PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE 1-27 PACAP-38 (1-27) AMIDE (HUMAN, MOUSE, OVINE, PORCINE, RAT) pituitary adenylate cyclase activating polypeptide-27 ovine Pituitary adenylatecyclase-activating peptide-27 (human) (9CI) PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE 27 AMIDE, OVINE PITUITARY ADENYLATE CYCLASE ACTIVATING PEPTIDE (1-27), HUMAN, OVINE, RAT PACAP-PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE (HUMAN, OVINE, RAT) PITUARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE 27 (HUMAN, 1-27 AMIDE) OVINE, RAT PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE (1-27) AMIDE (HUMAN, OVINE, RAT) PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE-27 (HUMAN, MOUSE, OVINE, PORCINE, RAT) [ARG14,20,21, LEU16] PITUITARY ADENYLATE CYCLASE ACTIVATING PEPTIDE (1-27), HUMAN, OVINE, RAT HIS-SER-ASP-GLY-ILE-PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ALA-ALA-VAL-LEU-NH2 HIS-SER-ASP-GLY-ILE-PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-ARG-GLN-LEU-ALA-VAL-ARG-ARG-TYR-LEU-ALA-ALA-VAL-LEU-NH2 H-HIS-SER-ASP-GLY-ILE-PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ALA-ALA-VAL-LEU-NH2 H-HIS-SER-ASP-GLY-ILE-PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ALA-ALA-VAL-LEU-NH2 H-HIS-SER-ASP-GLY-ILE-PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ALA-ALA-VAL-LEU-NH2 USP/EP/BP PACAP-38 (1-27) aMide (huMan, Mouse, ovine, porcine, rat), Pituitary Adenylate Cyclase Activating Polypeptide-27 (huMan, Mouse, ovine, porcine, rat) HIS-SER-ASP-GLY-ILE-PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ALA-ALA-VAL-LEU-GLY-LYS-ARG-TYR-LYS-GLN-ARG-VAL-LYS-ASN-LYS-NH2: HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK-NH2 L-Leucinamide, L-histidyl-L-seryl-L-α-aspartylglycyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-α-aspartyl-L-seryl-L-tyrosyl-L-seryl-L-arginyl-L-tyrosyl-L-arginyl-L-lysyl-L-glutaminyl-L-methionyl-L-alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-alanyl-L-alanyl-L-valyl-

Chemical Properties

density	1.45±0.1 g/cm3(Predicted)
storage temp.	−20°C
solubility	H2OPeptide Solubility and Storage Guidelines:1.??Calculate the length of the peptide.2.??Calculate the overall charge of the entire peptide according to the following table:3.??Recommended solution:
form	solid
color	white
Water Solubility	Soluble to 1 mg/ml in water
Sequence	His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-NH2
InChIKey	RZGBUJXSKLDAFE-XVTUQGJWNA-N

Safety Data

WGK Germany	3
Storage Class	11 - Combustible Solids

Raw materials And Preparation Products

Hazard Information

Chemical Properties

This product is made from the posterior pituitary gland of pigs, cattle, sheep, and other animals by dehydrating, drying, and grinding. It contains oxytocin (approximately 20 units) and a small amount of vasopressin (0.5 units). The two are structurally very similar, both being nonapeptides containing disulfide bonds. The powder is a pale yellow or light gray amorphous powder with a distinctive odor and is virtually insoluble in water. It stimulates the uterus and promotes milk secretion. High doses of oxytocin can dilate blood vessels, while high doses of vasopressin can constrict them and also have a diuretic effect.

Uses

Pituitary Adenylate Cyclase-Activating Polypeptide 1-27 (PACAP 1-27) is a neuropeptide that stimulates adenylyl cyclase.

Biological Functions

PACAP 1-27 is an endogenous neuropeptide and is the C-terminally truncated form of PACAP 38. PACAP 27 has considerable homology with vasoactive intestinal peptide (VIP) but is >100 fold more potent than VIP as an agonist of the PAC1 receptor. PACAP 27 functions in the control of anterior pituitary hormone secretion, vasodilation, adrenaline secretion, insulin secretion and immunosuppression.

Biological Activity

PACAP 1-27, also known as PACAP 27 Amide, is an endogenous neuropeptide showing considerable homology with vasoactive intestinal peptide (VIP). Potently stimulates adenylyl cyclase.

in vivo

The inhibitory effect of pituitary adenylate cyclase activating polypeptide (PACAP (1-27), human, ovine, rat) on the increase in total pulmonary resistance (RL) causes either by allergen or histamine in anaesthetized, ventilated guinea-pigs is studied. PACAP (1-27), human, ovine, rat given via i.v. infusion (0.045-4.5 nmol/kg/min) dose-dependently reduces the increase in RL caused by inhaled ovalbumin and histamine. At the highest dose, PACAP (1-27), human, ovine, rat prevented the increase in RL caused by ovalbumin and histamine completely. Infusion of PACAP (1-27), human, ovine, rat and the β2-adrenoceptor agonist, salbutamol (0.045-4.5 nmol/kg/min) inhibit the increase in RL similarly, but salbutamol increases the heart rate more than PACAP (1-27), human, ovine, rat^[3].

storage

Store at -20°C

Supplier

3B Pharmachem (Wuhan) International Co.,Ltd.

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