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Name Corticotropin
CAS 9002-60-2
EINECS(EC#) 232-659-7
Molecular Formula C207H308N56O58S
MDL Number MFCD00167432
Molecular Weight 4541.1

Chemical Properties

Corticotropin is used principally in diagnosis and rarely in treatment. It is inactive if taken orally and has to be injected like other peptide hormones.
Diagnostic use is to test the capacity of the adrenal cortex to produce cortisol. With the short synacthen test, the plasma cortisol concentration is measured before and 30 min and 60 min after an intramuscular injection of 250 micrograms of tetracosactide (Synacthen); a normal response is a rise in plasma cortisol concentration of more than 200 nmol/L or a peak of greater than 500 nmol/L at 30 or 60 min. In cases of uncertainty, the longer variants of the test require intramuscular injection of a depot (sustained-release) formulation, e.g. 1 mg daily for 3 days at 09:00 hours, with a short tetracosactide test performed on day 3.
Therapeutic use is seldom appropriate, as the peptide hormone must be injected. Selective glucocorticoid (without mineralocorticoid) action is not possible, and clinical results are irregular. Corticotropin cannot be relied on to restore adrenal cortisol output when a steroid is being withdrawn after prolonged therapy, as it does not restore function in the suppressed hypothalamic–pituitary part of the HPA axis.
storage temp.  −20°C
solubility  H2O: 1 mg/mL, clear, colorless
form  powder
Merck  13,136
CAS DataBase Reference 9002-60-2

Safety Data

Hazard Codes  Xn
Risk Statements 
Safety Statements 
WGK Germany  3
RTECS  GM7900000
HS Code  2937190000
Hazardous Substances Data 9002-60-2(Hazardous Substances Data)

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Hazard Information