ChemicalBook CAS DataBase List 127191-97-3

127191-97-3

Name	KN-62
CAS	127191-97-3
Molecular Formula	C38H35N5O6S2
MDL Number	MFCD00083180
Molecular Weight	721.84
MOL File	127191-97-3.mol

Synonyms

KN-2 N 62 KN-62 CS-756 KN-62 97% KN-62,97% KN 62;KN-2 KN 62; KN62 KN-62, 99+% KN-62, >=98% KN-62 USP/EP/BP KN-62;KN 62; KN62 KN-62 - CAS 127191-97-3 - Calbiochem 1-(N,O-BIS-(5-ISOQUINOLINESULFONYL)-*N-M ETHYL-L-TYR (S)-4-(2-(N-Methylisoquinoline-5-sulfonaMido)-3-oxo-3-(4-phenylp 1-[N,O-BIS-(5-ISOQUINOLINESULFONYL)-N-METHYL-L-TYROSYL]-4-PHENYLPIPERAZINE (1-(N,O-BIS-(5-ISOQUINOLINESULFONYL)-N-METHYL-L-TYROSYL)4-PHENYLPIPERAZINE) KN 62 (S)-4-(2-(N-Methylisoquinoline-5-sulfonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl is (S)-4-(2-(N-methylisoquinoline-5-sulfonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl isoquinoline-5-sulfonat (S)-4-(2-(N-methylisoquinoline-5-sulfonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl isoquinoline-5-sulfonate (S)-4-(2-(N-methylisoquinoline-5-suNLFonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl isoquinoline-5-suNLFonate 4-((2S)-2-((5-isoquinolinylsulfonyl)methylamino)-3-oxo-3-(4-phenyl-1-piperazinyl)propyl)phenylisoquinolinesulfonicacid [4-[(2S)-2-[isoquinolin-5-ylsulfonyl(methyl)amino]-3-oxo-3-(4-phenylpiperazin-1-yl)propyl]phenyl] isoquinoline-5-sulfonate 4-[(2S)-2-[(5-Isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl] phenylisoquinolinesulfonic acid ester 5-Isoquinolinesulfonicacid,4-[2-[(5-isoquinolinylsulfonyl)MethylaMino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenylester, (S)- 4-[(2S)-2-[(5-ISOQUINOLINYLSULFONYL)METHYLAMINO]-3-OXO-3-(4-PHENYL-1-PIPERAZINYL)PROPYL] PHENYL ISOQUINOLINESULFONIC ACID ESTER (s)-5-isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester (S)-5-ISOQUINOLINESULFONIC ACID 4-(2-[(5-ISOQUINOLINYLSULFONYL)METHYLAMINO]- 3-OXO-3-[4-PHENYL-1-PIPERAZINYL]PROPYL)PHENYL ESTER 5-Isoquinolinesulfonic acid, 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester 5-Isoquinolinesulfonic acid 4-[(S)-2-[[(isoquinolin-5-yl)sulfonyl]methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester noncompetitive antagonism,KN-62,KN 62,inhibit,P2XRs,Calmodulin-dependent protein kinases,HEK293 cells,P2X Receptor,Calmodulin-dependent kinases,CaMK,Inhibitor,autophosphorylation,KN62 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo- 3-(4-phenyl-1-piperazinyl)propyl]phenylisoquinolinesulfonicacid ester KN-62 1-(N,O-Bis-[5-isoquinolinesulfonyl]-N-methyl-L-tyrosyl)-4-phenylpiperazine, (S)-5-Isoquinolinesulfonic Acid 4-(2-[(5-Isoquinolinylsulfonyl)methylamino]- 3-oxo-3-[4-phenyl-1-piperazinyl]propyl)phenyl Ester, (S)-5-Isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester, 1-[N,O-bis(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine

Chemical Properties

Appearance	Yellow Solid
Melting point	92-94°C
Boiling point	964.7±75.0 °C(Predicted)
density	1.388
storage temp.	−20°C
solubility	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.93 mg/mL
form	solid
pka	4.07±0.13(Predicted)
color	white
biological source	synthetic (organic)
Usage	A specific inhibitor of Ca2+/Calmodulin-dependent protein kinase II
InChIKey	RJVLFQBBRSMWHX-DHUJRADRSA-N
SMILES	O=S(OC1=CC=C(C[C@@H](C(N2CCN(C3=CC=CC=C3)CC2)=O)N(C)S(C4=CC=CC5=C4C=CN=C5)(=O)=O)C=C1)(C6=CC=CC7=C6C=CN=C7)=O
CAS DataBase Reference	127191-97-3(CAS DataBase Reference)

Safety Data

Safety Statements	S24/25:Avoid contact with skin and eyes . less more
WGK Germany	3
HS Code	29339980
Storage Class	11 - Combustible Solids

Hazard Information

Chemical Properties

Yellow Solid

Uses

A specific inhibitor of Ca2+/Calmodulin-dependent protein kinase II

Uses

It is used as a potent and selective inhibitor of CaMKII. KN-62 has demonstrated potent and selective inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII; Ki=0.9 ?M) which causes cells to arrest in the S phase. In HEK-293 cells expressing type III adenylyl cyclase (III-AC), 10 ?M of KN-62 blocked CaMKII phosphorylation of III-AC, and inhibited hormone-stimulated Ca2+ oscillations. Additionally, KN-62 is a potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM).

Uses

selectively inhibits rat brain Ca2+/cadmodulin-dependent protein kinase II,

Definition

ChEBI: 5-isoquinolinesulfonic acid [4-[(2S)-2-[5-isoquinolinylsulfonyl(methyl)amino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl] ester is a member of piperazines.

General Description

A cell-permeable, reversible, and selective inhibitor of CaM kinase II (K_i = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme. Also inhibits the growth of K562 cells in a dose-dependent manner.

Biological Activity

Selective, cell-permeable inhibitor of CaM kinase II (IC 50 = 0.9 μ M). Binds directly to the calmodulin binding site of the enzyme. Potent non-competitive antagonist at the P2X 7 receptor (IC 50 = 15 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset™ .

Biochem/physiol Actions

Selectively inhibits rat brain Ca2+/calmodulin-dependent protein kinase II.

storage

-20°C (desiccate)

Spectrum Detail

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