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Gymnemic acid I is a triterpene glycoside that has been found in G. sylvestre and has antihyperglycemic activities. It inhibits glucose-induced phosphorylation of serine 70 on S6 kinase (S6K1) and serine 2448 on mTOR, caspase-3 activity, and apoptosis, as well as increases autophagy in MIN-6 pancreatic β cells when used at a concentration of 5 μg/ml. Gymnemic acid I has been used as a reference compound to compare the potency of plant-derived sweet taste inhibitors.

(+)-Gymnemic Acid I is one of the components extracted from the leaves of Gymnema sylvestre, known for inhibitory acitivity against glucose absorption. However, (+)-Gymnemic Acid I lacks this activity, unlike other forms of gymnemic acids.

ChEBI: Gymnemic acid I is a triterpenoid saponin.

[1] YANYANG WU. Gymnemic acid I triggers mechanistic target of rapamycin-mediated β cells cytoprotection through the promotion of autophagy under high glucose stress[J]. Journal of Cellular Physiology, 2018, 234 6: 9370-9377. DOI: 10.1002/jcp.27621
[2] KINGHORN A, CHIN Y, PAN L, et al. Natural Products as Sweeteners and Sweetness Modifiers[C]. 1900: 0. DOI: 10.1016/b978-008045382-8.00077-0