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Questions And Answer

• Description

  Melanotan II is a synthetic analogue of the melanocortin peptide hormone alpha-melanocyte stimulating hormone (α-MSH) that occurs naturally. In usage, Melanotan II has been revealed to have aphrodisiac and melanogenesis (tanning) effects that have been subjected to clinical trials and preliminary studies. The compound is a cyclic lactam analogue of α-MSH that has an amino sequence named MTII (Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2). Notably, no government drug regulatory agency across the world had approved for the use of any compound incorporating the Melanotan II peptide by 2010 ;

• Historical Development

  Melanotan II was first developed at the University of Arizona. Various studies conducted at the institution confirmed that the best defence against skin cancer was melanin activated in the skin, a tan. The researchers assumed that an effective procedure to reduce the rates of skin cancer in individuals would be by inducing the body’s natural pigmentary system to produce a tan that would be protective before exposure to UV. Melanogenesis is a process by which the skin’s pigment cells (melanocytes) produce the hormone α-MSH naturally causes the skin's pigment (melanin).
  After numerous clinical trials by administration of the endogenous hormone to the body, the scientists found that though it appeared to work, α-MSH had a very short half-life in the body to be practical as a therapeutic drug. Therefore, they opted to look for a more stable and potent alternative that would be more practical. Subsequently, after numerous trials, they developed Melanotan I and after that Melanotan II. ;

• Uses

  Malanotan II is used for tanning of the skin and producing of erections in men with erectile dysfunction when administered as a shot under the skin. Malanotan II is safe when used under strict medical supervision for treating erectile dysfunction. However, it may cause stomach cramps, tiredness, nausea, spontaneous erections of the penis, and darkened skin. ;

• BENEFITS OF A MELANOTAN II

  Darker tan with less exposure to UV radiation
  Tanning without sunburn, even for fair-skinned individuals
  Possible reduction in the risk of Melanoma (skin cancer)
  Possible reduction in the incidence of sun-damaged skin
  Possible reduction in body fat
  No sunburn, n tan lines
  No sunless tanning streaks or fake tan removal
  Possible increase libido
  During clinical trials for its use as a tanning agent, melanotan II was found to be a potent stimulator of male erections. It has also been shown to increase female sexual desire in patients with sexual arousal disorder).;

• SIDE EFFECTS

  Short term side effects after administration include:
  Facial flushing
  Reduced appetite, nausea and vomiting
  In males, spontaneous erections 1-5 hours after administration (priapism), associated with yawning and stretching complex
  Long term, there is concern that melanotan II may increase the risk of:
  Melanoma – a potentially serious form of skin cancer
  Deepening of the color of moles, new moles and atypical melanocytic naevi
  Melanonychia – brown to black discoloration of one or more nails
  Suggested usage: daily for 1 - 2 weeks then one to two times weekly for maintenance.;

• Controversy

  Melanotan II is widely sold online and in beauty salons as well as gyms as melanotan in their marketing. These products purport to contain the same chemical composition as afamelanotide. These products have been declared illegal and do not have the same chemical components as Melanotan II. As such, countries issues warnings against their use. ;

• Dosage

  Melanotan 2 has a half life of ~33 hours, this allows you to be very flexible with dosing. Recommended dosages start at 250mcg every day to help your body acclimatize to the peptide and minimize the side effects. You can continue with this dose indefinitely if you are intending to do a low dosage regimen.
  If you want to dose higher, after 2-4 days, whenever you feel comfortable, up the dose to 500mcg. 500mcg is the most common dosage amount administed by users. You can increase the dose as far as about 1mg but any higher is generally not advised and the users dosing 1mg/dose normally weigh around the 100kg mark.;

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