ChemicalBook CAS DataBase List 75921-69-6

75921-69-6

Name	Melanotan-1
CAS	75921-69-6
EINECS(EC#)	211-519-9
Molecular Formula	C78H111N21O19
MDL Number	MFCD00151715
Molecular Weight	1646.85
MOL File	75921-69-6.mol

Synonyms

AC-SER-TYR-SER-NLE-GLU-HIS-D-PHE-ARG-TRP-GLY-LYS-PRO-VAL-NH2 AC-SYS-NLE-EHFRWGKPV-NH2 MELANOTAN I NDP-MSH NDP-MSHAC-SER-TYR-SER-NLE-GLU-HIS-D-PHE-ARG-TRP-GLY-LYS-PRO-VAL-NH2 [NLE4,D-PHE7]-ALPHA-MELANOCYTE-STIMULATING HORMONE [NLE4,DPHE7] ALPHA-MELANOCYTE STIMULATING HORMONE, AMIDE (NLE4,D-PHE7)-ALPHA-MSH [NLE4, D-PHE7]-ALPHA-MSH, AMIDE [NLE4,D-PHE]ALPHA-MELANOCYTE STIMULATING HORMONE NLE-4-D-PHE-7-A-MELANOCYTE*STIMULATING H ORMONE [Nle4,D-Phe7]-MSHNDP-MSH [Nle4,D-Phe7] a-Melanocyte stimulating hormone,amide [nle4, d-phe7]-α-melanocyte stimulating hormone trifluoroacetate salt MSH, 4-Nle-7-Phe-alpha- Melanotan I Acetate MelanotanⅠ(α-MSH) 4-Nle-7-phe-alpha-msh 4-Norleucyl-7-phenylalanine-alpha-msh Melanotan-1 Melanotropin

Chemical Properties

density	1.46±0.1 g/cm3(Predicted)
RTECS	OS1830200
storage temp.	−20°C
form	Solid
pka	4.43±0.10(Predicted)
Water Solubility	Soluble to 0.60 mg/ml in sterile water
Sequence	Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
InChIKey	UAHFGYDRQSXQEB-LEBBXHLNSA-N
CAS DataBase Reference	75921-69-6(CAS DataBase Reference)

Safety Data

WGK Germany

Hazard Information

Uses

Melanotan 1 is a highly potent melanotropin with extended biological activity and resistance to enzymatic degredation by serum enzymes. [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt has been used to detect its effect on O2 consumption and CO2 production in C57BL/6 mice. It is also used to determine its effect on leptin secretion in the primary cultures of differentiated adipocytes.

Definition

ChEBI: Afamelanotide is a polypeptide comprising of 13 amino acids which is an analogue of alpha-melanocyte stimulating hormone. It is approved as a dermatologic drug for the prevention of phototoxicity in adult patients with erythropoietic protoporphyria. It has a role as a dermatologic drug.

General Description

[Nle4, D-Phe7]-α-melanocyte stimulating hormone is a potent analogue of α;-melanocyte-stimulating hormone (α -MSH). αMSH is a tridecapeptide, mostly produced by the cells in the brain, pituitary and in circulation.

Biochem/physiol Actions

[Nle4, D-Phe7]-α-melanocyte stimulating hormone is 100 times more potent than α-MSH in stimulating melanoma tyrosinase, which is a rate limiting enzyme in melanin biosynthesis and is 26 times as potent as α-MSH in S91adenylate cyclase assay. α –MSH has an essential role to play in melanin production in animals. It also regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases.

Side effects

The TGA has previously warned consumers against the use of Melanotan-I and Melanotan-II for tanning and weight loss. Side-effects include darkened skin, increased moles and freckles, nausea, vomiting, loss of appetite, flushing of the face, involuntary stretching and yawning, and spontaneous erections.

storage

Store at -20°C

Questions And Answer

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