1141-23-7

84803-46-3

1141-23-7

General procedure for the synthesis of 3-(4-chlorophenyl)glutaric acid monoamide from 3-(4-chlorophenyl)glutaric acid monoamide: Intermediate IV (120 g, 0.537 mol) was taken, aqueous sodium hydroxide solution (600 μl, 15N) was added, and the reaction was stirred for 1.5 hr at 65-70 °C. After the reaction was completed, it was cooled to room temperature and toluene (500 ml) and deionized water (700 ml) were added. The mixture was stirred for 20 min, and the organic layer was discarded after standing and layering. The pH of the aqueous layer was adjusted to 2~3 with concentrated hydrochloric acid, left to stand and filtered, and the solids were washed with water. The solid was dried under vacuum at 55~60°C for 5 hours to give 116 g of white solid intermediate V in 89.5% yield.