1068-57-1

White moist crystals and chunks

Acetohydrazide is a metabolite of Isoniazid (I821450) an antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis.

ChEBI: A carbohydrazide that is hydrazine in which one of the hydrogens is replaced by an acetyl group.

A kind of preparation method of acethydrazide include the following steps: Under nitrogen protection, by acetic acid, hydrazine hydrate It is put into catalyst in the reaction kettle with rectifying column, opens stirring, be heated to reflux, after steam enters rectifying column, Vapor are produced in tower top temperature for 98 DEG C~100 DEG C, when reaction 4~6 is small at a reflux temperature, when rectifying tower top frozen-free current Reaction terminates after going out, and continues heating distillation, and the acetic acid and hydrazine hydrate of reaction are had neither part nor lot in 100 DEG C~120 DEG C extraction of tower top temperature, After acetic acid and hydrazine hydrate are all steamed, liquid in kettle is poured out into filtering while hot, filtrate is through crystallisation by cooling, pure water, very Acethydrazide finished product is obtained after sky is dry.

Acetic hydrazide crystallises as needles from EtOH. It reduces NH3/AgNO3. [Beilstein 2 H 191, 2 IV 435.]

[1] S. Nzikayel, A. Ec, Akpan Ij. “Synthesis, FTIR and Electronic Spectra Studies of Metal (II) Complexes of Acethydrazide Derivative.” Medicinal Chemistry 8 1 (2018): 26–28.
[2] S. Pakdehi, A. S. Moghaddam, M. Sohrabi. “Liquid phase hydrogenation of acethydrazone to N’-methyl acethydrazide over Pd/γ-Al2O3 catalyst.” Brazilian Journal of Chemical Engineering 27 1 (2010): 145–152.