105496-35-3

LY 190388 is a penicillamine-containing enkephalin analog. It is an mu receptor agonist that produces analgesia..

LY 190388 is a penicillamine-containing enkefa peptide analog with μ receptor agonist activity. LY 190388 showed analgesic effect in inhibiting the writhing response in mice after intracerebroventricular administration. The analgesic effect of LY 190388 is not caused by its δ receptor agonist action, but by its μ receptor agonist activity. When LY 190388 is used together with the δ receptor antagonist ICI 174864, an additive analgesic effect is produced[1].

[1] Comparison of two penicillamine-containing enkephalins: mu, not delta, activity produces analgesia