1048007-93-7

790299-79-5

75-75-2

1048007-93-7

Synthesis of N-(4-methyl-3-((4-(pyridin-3-yl)thiazol-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide and methanesulfonic acid as 4-[(4-methyl-1-piperazinyl)methyl]-N-(4-methyl-3-((4-(pyridin-3-yl)thiazol-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamidic acid The general procedure for the sulfonate is as follows: 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]benzamide (1.0 eq.) was dissolved in ethanol (4.5 v/v), and heated to 65-70°C to dissolve it completely. Under the condition of maintaining the same temperature, methanesulfonic acid (1.0 eq.) was slowly added. Upon completion of the reaction, the mixture was cooled to 25-30 °C and kept at this temperature for 6 hours to promote crystallization. The product was collected by filtration and dried in a vacuum disk dryer at 55-60°C. The yield of this step was 85-90% and the starting melting point of the product was 236°C.