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10416-59-8

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Identification

Name
N,O-Bis(trimethylsilyl)acetamide
CAS
10416-59-8
Synonyms
BIS(TRIMETHYLSILYL)ACETAMIDE
BSA
dynasylan bsa
N,O-BIS(TRIMETHYLSILYL)ACETAMIDE
TMS-BA
Trimethylsilyl N-trimethylsilylacetamidate
Acetimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester
bis(trimethylsllyl)acetamide
CB2500
Ethanimidicacid,N-(trimethylsilyl)-,trimethylsilylester
N-(Trimethylsilyl)acetimidic acid, trimethylsilyl ester
n-(trimethylsilyl)acetimidicacid,trimethylsilylester
n-(trimethylsilyl)-acetimidicacitrimethylsilylester
n-(trimethylsilyl)-ethanimidicacitrimethylsilylester
Trimethylsilyl (1E)-N-[(E)-trimethylsilyl]ethanimidoate
NO-Bis (trimethylsilyl) acetamide 90+ % gas chromatography
N.O-Bis(trimethylsilyl)acetamide (BSA)
N,O-BIS(TRIMETHYLSILYL)ACETAMIDE SET WIT H 10 X 1 ML
N,O-Bis(trimethyl-d9-silyl)acetamide (BSA-d18), 98% CP, 99 atom % D
N,O-BIS(TRIMETHYLSILYL)ACETAMIDE, FOR GC
EINECS(EC#)
233-892-7
Molecular Formula
C8H22NOSi2
MDL Number
MFCD00008270
Molecular Weight
204.44
MOL File
10416-59-8.mol

Chemical Properties

Appearance
Clear to yellowish clear liquid
mp 
24 °C
bp 
71-73 °C35 mm Hg(lit.)

density 
0.832 g/mL at 20 °C(lit.)

refractive index 
n20/D 1.417(lit.)

Fp 
53 °F

storage temp. 
0-6°C
Sensitive 
Moisture Sensitive
Detection Methods
GC
BRN 
1306669
CAS DataBase Reference
10416-59-8(CAS DataBase Reference)
NIST Chemistry Reference
Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester(10416-59-8)
EPA Substance Registry System
10416-59-8(EPA Substance)

Safety Data

Hazard Codes 
C,Xn,F
Risk Statements 
R10:Flammable.
R14:Reacts violently with water.
R22:Harmful if swallowed.
R34:Causes burns.
R40:Limited evidence of a carcinogenic effect.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R11:Highly Flammable.
Safety Statements 
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S7/8:Keep container tightly closed and dry .
S36:Wear suitable protective clothing .
S30:Never add water to this product .
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S16:Keep away from sources of ignition-No smoking .
S7/9:Keep container tightly closed and in a well-ventilated place .
RIDADR 
UN 2920 8/PG 2

WGK Germany 
3

RTECS 
AK3000000


10-21
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29310095

Raw materials And Preparation Products

Material Safety Data Sheet(MSDS)

Questions And Answer

Description
Clear to yellowish clear liquid liquid which is soluble in many nonpolar and polar aprotic solvents.
The trimethylsilyl group is a frequently utilized monofunctional blocking group for protic organic and inorganic materials. As it eliminated during the silylation is neutral acetamide, N,O-Bis(trimethylsilyl)acetamide can be preferably used for substrates which are acid- or base-sensitive.
N,O-bis(trimethylsilyl)-acetamide is an effective silylating agent. It is used in the pharmaceutical and in the chemical industry. Typically the silylating reaction with BSA results in neutral by-products only.
Uses
  1. Used for blocking and protection of hydroxyl groups in natural products, e.g. amino acids, carbohydrates;
  2. Used for blocking and protection of functional groups in organic intermediates;
  3. Used for formation of derivatives of H-acid compounds for analysis;
The silylated derivatives are volatile and can therefore be determined by gas chromatography. Deblocking is preferably carried out by means of hydrolysis, giving high yields. In some cases, thermal elimination of the trimethylsilyl group is possible.

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