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Flazasulfuron is a sulfonylurea herbicide used to control a wide range of annual and perennial weeds. It has a high aqueous solubility and a low volatility. Evidence suggests it is not persistent in soil systems. Its persistence in water bodies may be very high depending on local conditions. Based on physico-chemical properties, flazasulfuron is not expected to leach to groundwater. It is moderately toxic to most species with the main exception being aquatic plants for which ecotoxicity is high. It has a low mammalian oral toxicity and there are some concerns that this substance may be a reproduction/developmental toxin.

Herbicide.

ChEBI: Flazasulfuron is a sulfonamide and a member of pyridines.

Flazasulfuron is commercially produced through a multi-step synthesis that constructs its complex heterocyclic structure. The process typically begins with the preparation of a 4,6-dimethoxypyrimidine derivative, which is then reacted with a sulfonamide-bearing pyridine ring containing a trifluoromethyl group. The key step involves forming the sulfonylurea linkage by coupling the pyrimidine carbamoyl chloride intermediate with the sulfonamide under controlled conditions, often in the presence of a base and an organic solvent. The reaction is carefully managed to ensure high purity and yield, followed by purification steps such as crystallisation or solvent extraction.

Systemic, absorbed through leaves. Inhibits plant amino acid synthesis - acetohydroxyacid synthase AHAS

Herbicide