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Esculentic acid has anti-inflammatory effect. Esculentic acid has protective effects against LPS-induced endotoxic shock may be mediated, at least in part, by regulation the release of inflammatory cytokines and mediators, and protein expression of COX-2 in mice.

Esculentic acid is a selective COX-2 inhibitor and has anti-inflammatory effect. Esculentic acid is a pentacyclic triterpenoid that can be extracted from the Chinese herb Phytolacca esculenta[1][2].

ChEBI: 2alpha,3alpha,23-trihydroxyurs-12-en-28-oic acid is a pentacyclic triterpenoid that is urs-12-ene substituted by a carboxy group at position 28 and hydroxy groups at positions 2, 3 and 23 (the 2alpha,3alpha stereoisomer). It has been isolated from Juglans sinensis. It has a role as a plant metabolite. It is a pentacyclic triterpenoid and a hydroxy monocarboxylic acid. It derives from a hydride of an ursane.

COX | TNF-α | IL Receptor

[1] Niu X, et al. Esculentic acid, a novel and selective COX-2 inhibitor with anti-inflammatory effect in vivo and in vitro. Eur J Pharmacol. 2014 Oct 5;740:532-8. DOI:10.1016/j.ejphar.2014.06.034
[2] Niu X, et al. Protective effects of esculentic acid against endotoxic shock in Kunming mice. Int Immunopharmacol. 2014 Nov;23(1):229-35. DOI:10.1016/j.intimp.2014.08.022