Hazard Information
Uses
Sarecycline-d6 Hydrochloride is a labelled analogue of Sarecycline Hydrochloride(S140525), which is a substituted tetracycline compound used for treatment of bacterial infections and neoplasms.
in vivo
Sarecycline hydrochloride (0.33-9? mg/kg; i.v.) show potent activity against S. aureus in a murine neutropenic thigh infection model[1].
Sarecycline can inhibit S. aureus (PD50=0.25 mg/kg), but has no significant effect on E. coli even at the highest dose (>40 mg/kg) in CD-1 mice model of systemic (intraperitoneal) infection[6].
Sarecycline (1-150mg/kg; Intraperitoneal injection; Single dose) shows anti-inflammatory activity in Sprague Dawley rats model[6].
| Animal Model: | Carrageenan-induced footpad edema male Sprague Dawley rats model[6] |
| Dosage: | 1 mg/kg, 5 mg/kg ,10 mg/kg, 25 mg/kg, 50 mg/kg, 75 mg/kg,100 mg/kg, 150 mg/kg |
| Administration: | Intraperitoneal injection (i.p.); Single dose. Before a subplantar injection of sterile 1 mg/0.1 mL carrageenan solution in the right hind paw. |
| Result: | Reduced inflammation to 55.7% and 53.1%, respectively, at doses of 75 mg/kg and 100 mg/kg compared to baseline. |
| Animal Model: | Carrageenan-induced footpad edema male Sprague Dawley rats model[6] |
| Dosage: | 0.33, 1, 3, or 9?mg/kg |
| Administration: | Intravenously |
| Result: | Achieved a 2-log10 reduction in the bacterial burden in the thigh at a dose comparable to that of doxycycline, with ED50s of 8.23 and 8.32?mg/kg, respectively. |
IC 50
Tetracycline
Supplier
Shanghai Chaolan Chemical Technology Center
Telephone021-QQ：65489617 15618227136
Websitehttp://www.atkchemical.com/
Amadis Chemical Company Limited
Telephone571-89925085
Websitehttp://www.amadischem.com
Hubei Yangxin Medical Technology Co., Ltd.
Telephone 15374522761
Websitehttp://www.standardpharm.com
SuZhou Medinoah Co.,LTD.
Telephone0512-69561983 13914027025
Websitehttp://www.medinoah.com/
AFINE CHEMICALS LIMITED
Telephone+86-0571-85134551
Websitehttp://www.afinechem.com/index.html
Guangzhou Dreampharm Biotechnology Co., Ltd.
Telephone020-36607679 17825480238
Websitehttp://www.dmstandards.com/
Jinan blalong chemical co. LTD
Telephone 2710913286@.com
Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1068244/0.htm
Guangzhou Juntang Technology Co., Ltd
Telephone020-36607679 13502246435
Websitehttp://www.dmstandards.com
Wuhan Topule
Telephone+86-02787215551 +86-19945035818
Websitehttp://www.topule.com/
QUALITY CONTROL SOLUTIONS LTD.
Telephone0755-66853366; 13670046396
Websitehttps://www.qcsrm.com
Hubei Kele Fine Chemical Co., Ltd
Telephone027-59101668 19945030958
Websitehttp://www.kerle.cn
Wuhan Augda Biotechnology Co., Ltd
Telephone 15071299552
Websitehttps://www.chemicalbook.com/supplier/24275232/1.htm
InvivoChem
Telephone 13549236410
Websitehttps://www.invivochem.cn/
Suzhou Daolan Biomedical Technology Co., Ltd.
Telephone 15952404857
Websitehttp://www.dolanpharm.com/
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.
Telephone+86-027-59232304 15387063101
Websitehttps://www.yingnor.com/
Scinova Biotech(Guangzhou) Co., Ltd.
Telephone 13268215580
Websitehttp://www.scinova-e.com/
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Telephone025-66113011 18112977050
Websitehttp://www.aikonchem.com
Hubei De'ao Chemical Research Pharmaceutical Technology Co., Ltd
Telephone18502726233; 18502726233
Websitehttps://www.chemicalbook.com/supplier/25403897/
1of4
PROMPT×
PROMPT
The What'sApp is temporarily not supported in mainland China
The What'sApp is temporarily not supported in mainland China
Cancel
Determine