Carbocistein

Bezeichnung:Carbocistein

CAS-Nr638-23-3

Englisch Name:S-Carboxymethyl-L-Cysteine

CBNumberCB7467567

SummenformelC5H9NO4S

Molgewicht179.19

MOL-Datei638-23-3.mol

Synonyma

Carbocistein

Carbocistein physikalisch-chemischer Eigenschaften

Schmelzpunkt	208-213 °C (dec.)
Siedepunkt	417.3±45.0 °C(Predicted)
alpha	-31 º (c=1, 10% NaH2CO3)
Dichte	1.315 (estimate)
Brechungsindex	1.5216 (estimate)
storage temp.	2-8°C
Löslichkeit	Aqueous Acid, Aqueous Base (Sparingly, Sonicated)
pka	2.06±0.10(Predicted)
Aggregatzustand	Amorphous Powder
Farbe	White to slightly off-white
Wasserlöslichkeit	SOLUBLE IN COLD WATER
Merck	14,1802
BRN	1725012
LogP	0.204 (est)
CAS Datenbank	638-23-3(CAS DataBase Reference)
EPA chemische Informationen	L-Cysteine, S-(carboxymethyl)- (638-23-3)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	24/25-36-26
WGK Germany	2
RTECS-Nr.	AY4342000
TSCA	Yes
HS Code	29309090
Toxizität	LD50 oral in rat: > 15gm/kg

Gefahreninformationscode (GHS)

S-Carboxymethyl-L-Cysteine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
white to slightly off-white amorphous powder
Originator
Rhinathiol,Kramer,Switz.
Verwenden
Labeled Carbocisteine, intended for use as an internal standard for the quantification of Carbocisteine by GC- or LC-mass spectrometry.
Verwenden
Carbocisteine is a mucolytic agent used in the treatment of respiratory disorders ranging from the influenza virus infection to chronic obstructive pulmonary disease (COPD).
Verwenden
carbocysteine is an amino acid. It can be used to help control sebum production.
Definition
ChEBI: S-carboxymethyl-L-cysteine is an L-cysteine thioether that is L-cysteine in which the hydrogen of the thiol group has been replaced by a carboxymethyl group. It has a role as a mucolytic. It is a L-cysteine thioether and a non-proteinogenic L-alpha-amino acid. It is a conjugate acid of a S-carboxylatomethyl-L-cysteine(1-).
Manufacturing Process
There were placed 120g of L-cysteine (0.5 mol) in a 2 liter three-necked flask equipped with a stirrer thermometer and methanol/dry ice cooling and 1.5 liters of liquid ammonia were allowed to enter at -40°C. Then there were added under continuous cooling 50 g (2.17 mols) of sodium metal in portions of 1 to 2 g during the course of one hour. The end of the reaction was recognized by the continuation of the blue color. After the end of the reaction the excess sodium was destroyed by the addition of ammonium chloride and the ammonia vaporized at normal pressure. The residue was taken up in 500 ml of water and concentrated in a vacuum to 200 ml in order to remove residual ammonia, and again treated with 300 ml of water. The entire operations were carried out under a nitrogen atmosphere.
The aqueous solution of the disodium salt of L-cysteine obtained is then reacted at 20°C to 30°C under a nitrogen atmosphere in the course of 30 minutes with stirring with a solution of 104 g of chloroacetic acid (1.1 mols) and 4 g of sodium pyrosulfite in 200 ml of water. It is also allowed to post react for 15 minutes at 20°C, the solution clarified over activated carbon and the filtrate treated with 90 ml of concentrated hydrochloric acid to a pH of 2.5.
Thereby the S-carboxymethyl-L-cysteine precipitates out in crystalline form. The product is filtered off with suction, well stirred in 500 ml of water, again filtered with suction and dried in a vacuum at 70°C. The yield is 92% based on L-cysteine.
Trademarks
Loviscol (Wyeth-Ayerst); Mucofan (Wyeth-Ayerst).
Therapeutic Function
Mucolytic, Expectorant, Nasal antiinfective
Biochem/physiol Actions
S-Carboxymethyl-L-cysteine is studied as a small molecule mucoactive drug in vivo. These studies include analyzing the oxidative metabolism of S-carboxymethyl-L-cysteine by enzymes such as phenylalanine monooxygenase(s).
Sicherheitsprofil
contact. A riot control agent. When heated

S-Carboxymethyl-L-Cysteine Upstream-Materialien And Downstream Produkte

Carbocistein Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

638-23-3, S-Carboxymethyl-L-Cysteine Verwandte Suche:

Send Inquriy