乳酸甲氧苄啶
乳酸甲氧苄啶 性质
| 熔点 | 170 - 172°C |
|---|---|
| 储存条件 | Keep in dark place,Inert atmosphere,2-8°C |
| 溶解度 | H2O：可溶，20mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色 |
| 水溶解性 | Soluble in water |
| CAS 数据库 | 23256-42-0(CAS DataBase Reference) |
乳酸甲氧苄啶 用途与合成方法
Dihydrofolate reductase
Bacteria
Trimethoprim interrupts folate metabolism by inhibition of the activity of dihydrofolase reductase (DHFR), which reduces dihydrofolate to tetrahydrofolate (THF).
Trimethoprim causes protein aggregation and induction of main heat shock proteins (Hsps) in E. coli cells, which indicates that Trimethoprim presence leads to protein misfolding. Trimethoprim causes induction of DnaK, DnaJ, GroEL, ClpB, and IbpA/B Hsps. Among these Hsps, IbpA/B are most efficiently induced by Trimethoprim and coaggregates with the insoluble proteins. Upon folate stress, deletion of the delta ibpA/B operon resulted in increased protein aggregation but does not influence cell viability.
In intraperitoneal infections in mice, the CD 50 values for Trimethoprim alone against H. influenzae , S. pneumoniae , E. coli and N. meningitidis , is 150 mg/kg, 335 mg/kg, 27.5 mg/kg and 8.4 mg/kg, respectively.
安全信息
| 危险品标志 | T |
|---|---|
| 危险类别码 | 23/24/25-43-61 |
| 安全说明 | 22-36/37/39-45-53 |
| 危险品运输编号 | UN 2811 |
| WGK Germany | 3 |
| 危险等级 | 6.1(b) |
| 包装类别 | III |
乳酸甲氧苄啶 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-B0510C | 乳酸甲氧苄啶 | 23256-42-0 | 500mg | 500 |
| 2024-01-25 | HY-B0510C | 乳酸甲氧苄啶 | 23256-42-0 | 10mM * 1mLin DMSO | 550 |
