VX 702

$25 - $5328

Product nameVX 702
Cas No745833-23-2
MFC19H12F4N4O2
MW404.32
MDL NumberMFCD11616590

Synonyms

6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide;VX 702;6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide VX-702;VX 702 6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide;VX702;VX-702;2-(2,4-Difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide;CS-1840;3-Pyridinecarboxamide, 6-[(aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-

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Price

55 prices

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TCI Chemical Sigma-Aldrich Cayman Chemical Arctom Crysdot AvaChem TRC Usbiological Biorbyt Ltd ApexBio Technology Matrix Scientific Adipogen Life Sciences Medical Isotopes, Inc. Apolloscientific ChemScene Biosynth DC Chemicals
Package less more

2mg 10mm(in1mldmso) 1mg 2.5mg 10mm*1mlindmso 5mg 10mg 20mg 25mg 50mg 100mg 200mg 250mg 1g 5g 50.00g 100.00g 250.00g

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Brand	Packaging	Price	Product name
Adipogen Life Sciences SYN-1093-M001	1mg	$54	VX-702
Adipogen Life Sciences SYN-1093-M005	5mg	$65	VX-702
Adipogen Life Sciences SYN-1093-M010	10mg	$76	VX-702
Adipogen Life Sciences SYN-1093-M050	50mg	$238	VX-702
Adipogen Life Sciences SYN-1093-M100	100mg	$378	VX-702
Adipogen Life Sciences SYN-1093-M100	100mg	$378	VX-702
ApexBio Technology A8687	100mg	$209	VX-702
ApexBio Technology A8687	200mg	$319	VX-702
ApexBio Technology A8687	50mg	$141	VX-702
ApexBio Technology A8687	25mg	$77	VX-702

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Properties

Boiling point	555.2±60.0 °C(Predicted)
Density	1.503
storage temp.	-20°C
solubility	Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 2 mg/ml)
form	solid
pka	10.65±0.50(Predicted)
color	White
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI	1S/C19H12F4N4O2/c20-9-4-5-10(14(23)8-9)16-11(18(24)28)6-7-15(26-16)27(19(25)29)17-12(21)2-1-3-13(17)22/h1-8H,(H2,24,28)(H2,25,29)
InChIKey	FYSRKRZDBHOFAY-UHFFFAOYSA-N
SMILES	Fc1c(c(ccc1)F)N(c2nc(c(cc2)C(=O)N)c3c(cc(cc3)F)F)C(=O)N
CAS DataBase Reference	745833-23-2

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H315：Causes skin irritation

H319：Causes serious eye irritation

Precautionary statements

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313：IF SKIN irritation occurs: Get medical advice/attention.

P337+P313：IF eye irritation persists: Get medical advice/attention.

Description

VX-702 is a third generation inhibitor of p38 mitogen-activated protein (MAP) kinases, binding to both p38α and p38β (Kd = 3.7 and 17 nM, respectively) in an ATP-competitive fashion. It inhibits IL-6, IL-1β, and TNF-α production in LPS-primed blood with IC50 values of 59, 122, and 99 ng/ml, respectively. VX-702, at 1 μM, inhibits activation of p38 in platelets by thrombin, U-46619 , or collagen but does not block platelet aggregation in response to collagen. Although orally active, VX-702 provides only transient suppression of biomarkers of inflammation in ongoing rheumatoid arthritis.

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Suppliers and manufacturers

career henan chemical co

$7.00/1KG

VX 702

CAS: 745833-23-2
TargetMol Chemicals Inc.

$45.00/10mg

VX-702

CAS:745833-23-2
ATK CHEMICAL COMPANY LIMITED
CONIER CHEM AND PHARMA LIMITED
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
Nantong HI-FUTURE Biology Co., Ltd.
SUZHOU SENFEIDA CHEMICAL CO.,LTD
Zhengzhou Anbu Chem Co.,Ltd

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