SB 203580

$26 - $2151

Product nameSB 203580
Cas No152121-47-6
MFC21H16FN3OS
MW377.43
MDL NumberMFCD00922198

Synonyms

SB 203580 HYDROCHLORIDE;SB 2035850;4-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-5-(4-PYRIDYL) 1H-IMIDAZOLE;4-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-5-(4-PYRIDYL)1H-IMIDAZOLE, HCL;4-[5-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-3H-IMIDAZOL-4-YL]PYRIDINE;4-[5-(4-FLUOROPHENYL)-2-[4-(METHYLSULFONYL)PHENYL]-1H-IMIDAZOL-4-YL]PYRIDINE;4-[5-(4-FLUOROPHENYL)-2-[4-(METHYLSULPHONYL)PHENYL]-1H-IMIDAZOL-4-YL]PYRIDINE HYDROCHLORIDE;4-[5-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-4-yl]pyridine

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Price

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TCI Chemical Sigma-Aldrich Cayman Chemical CSNpharm Arctom Chemenu Crysdot Tocris TRC Biorbyt Ltd ApexBio Technology Matrix Scientific AK Scientific Adipogen Life Sciences Axon Medchem Medical Isotopes, Inc. Chem-Impex Apolloscientific ChemScene American Custom Chemicals Corporation Biosynth Carbosynth Ambeed DC Chemicals
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1unit 10 1mg 10mg 1 5mg 50 10mm(in1mldmso) 20mg 25mg 50mg 100mg 200mg 250mg 500mg 1g 1ml

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Brand	Packaging	Price	Product name
Adipogen Life Sciences AG-CR1-0030-M025	25mg	$300	SB 203580
AK Scientific SYN1074	5mg	$85	SB 203580
Ambeed A248150	5mg	$26	SB 203580
Ambeed A248150	10mg	$41	SB 203580
Ambeed A248150	50mg	$108	SB 203580
Ambeed A248150	100mg	$195	SB 203580
Ambeed A248150	250mg	$289	SB 203580
Ambeed A248150	1g	$706	SB 203580
American Custom Chemicals Corporation KIN0000222	25MG	$720.12	SB 203580
American Custom Chemicals Corporation KIN0000222	50MG	$766.69	SB 203580

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Properties

Melting point	144-146
Boiling point	615.6±55.0 °C(Predicted)
Density	1.4
storage temp.	-20°C
solubility	DMSO: 50 mg/mL
form	solid
pka	9.60±0.10(Predicted)
color	white to off-white
Stability	-200C
InChI	InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)
InChIKey	CDMGBJANTYXAIV-UHFFFAOYSA-N
SMILES	C1=NC=CC(C2NC(C3=CC=C(S(C)=O)C=C3)=NC=2C2=CC=C(F)C=C2)=C1
CAS DataBase Reference	152121-47-6(CAS DataBase Reference)

Safety Information

Symbol(GHS)

Signal word

Danger

Hazard statements

H302：Harmful if swallowed

H318：Causes serious eye damage

Precautionary statements

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P270：Do not eat, drink or smoke when using this product.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501：Dispose of contents/container to..…

Description

Mitogen-activated protein kinases (MAPK) mediate signal transduction from cell surface receptors to the nucleus and are classified into various subtypes. p38 MAPK is activated by environmental stresses and inflammatory cytokines and is critical for normal immune and inflammatory responses as it regulates the expression of many cytokines, transcription factors, and cell surface receptors. SB 203580 is a pyridinyl imidazole inhibitor of p38 MAPK that specifically blocks its kinase activity. SB 203580 does not however, disrupt JNK activity, which is activated by similar stressors to those which activate p38 MAPK. p38 MAPK activity in heat-shocked HeLa cells and osmotically stressed PC12 cells is inhibited by SB 203580 with an IC50 value of 0.6 μM. SB 203580 also prevents the activation of PKB/Akt by inhibiting phosphoinositide-dependent protein kinase 1 (PDK1) at IC50 values of 3-5 μM.

Related product price

SB 203580 (hydrochloride) $42-874 SCH772984 $37-2400 PD 98059 $19-4662

Suppliers and manufacturers

career henan chemical co

$3.00/1KG

SB 203580

CAS:152121-47-6
TargetMol Chemicals Inc.

$30.00/5mg

Adezmapimod

CAS:152121-47-6
Capot Chemical Co.,Ltd.
Henan Tianfu Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
Biochempartner
BOC Sciences
Alchem Pharmtech,Inc.
CONIER CHEM AND PHARMA LIMITED
HANGZHOU CLAP TECHNOLOGY CO.,LTD

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