SR 1001

$32 - $795

Product nameSR 1001
Cas No1335106-03-0
MFC15H13F6N3O4S2
MW477.4
MDL NumberMFCD23160036

Synonyms

SR 1001;SR1001,N-{4-Methyl-5-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoroMethyl-ethyl)-phenylsulfaMoyl]-thiazol-2-yl}-acetaMide;N-(5-(N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)sulphamoyl)-4-methylthiazol-2-yl)acetamide;N-(5-{[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxy-2-propanyl)phenyl]sulfamoyl}-4-methyl-1,3-thiazol-2-yl)acetamide;N-[4-Methyl-5-[[[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]sulfonyl]-2-thiazolylacetamide;SR-1001;SR 1001;Acetamide, N-[4-methyl-5-[[[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]sulfonyl]-2-thiazolyl]-;SR1001 >=98% (HPLC)

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Price

20 prices

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Sigma-Aldrich Cayman Chemical Crysdot TRC ApexBio Technology AK Scientific ChemScene Ambeed DC Chemicals
Package less more

1mg 5mg 10mg 25mg 50mg 100mg

Clear All Done

Brand	Packaging	Price	Product name
AK Scientific 4062AH	25mg	$477	SR1001
Ambeed A240693	10mg	$196	SR-1001
Ambeed A240693	50mg	$332	SR-1001
Ambeed A240693	5mg	$114	SR-1001
ApexBio Technology B5742	10mg	$150	SR1001
ApexBio Technology B5742	50mg	$620	SR1001
Cayman Chemical 10922	5mg	$106	SR 1001
Cayman Chemical 10922	1mg	$32	SR 1001
Cayman Chemical 10922	25mg	$404	SR 1001
Cayman Chemical 10922	10mg	$186	SR 1001

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Properties

Density	1.640±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	DMSO: >5mg/mL
pka	5.90±0.50(Predicted)
form	powder
color	white to beige
Stability	Stable for 2 years from date of purchase as supplied. Protect from moisture. Solutions in DMSO may be stored at -20° for up to 3 months.

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H302：Harmful if swallowed

H319：Causes serious eye irritation

Precautionary statements

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P270：Do not eat, drink or smoke when using this product.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313：IF eye irritation persists: Get medical advice/attention.

Description

Retinoic-acid-receptor-related orphan receptors (ROR) α and γ play a key role in the development of T-helper cells that produce interleukin-17 (TH17 cells), a subset of CD4+ T-cells that contribute to the inflammatory process and have been implicated in the pathology of autoimmune diseases. SR 1001 is a synthetic ligand specific for RORα and RORγ (Kis = 172 and 111 nM, respectively) that functions as an inverse agonist at these receptors. SR 1001 has been shown to suppress IL-17 promoter driven transcriptional activity by inhibiting the interaction of co-activators such as TRAP220 nuclear receptor box 2 peptide (IC50 = 117 nM) and SRC2 with RORα and RORγ as well as by increasing the recruitment of corepressors such as NCoR. At 5 μM, SR 1001 inhibits TH17 cell differentiation and IL-17A secretion in cultured splenocytes and human PBMCs. A 25 mg/kg dose of SR 1001 twice/day delays the onset and the severity of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis.

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Suppliers and manufacturers

TargetMol Chemicals Inc.

$34.00/1mg

SR1001

CAS:1335106-03-0
InvivoChem
TargetMol Chemicals Inc.
Wuhan Topule Biopharmaceutical Co., Ltd
LEAPCHEM CO., LTD.
Aladdin Scientific
Amadis Chemical Company Limited
Shanghai Xiannuo Biotechnology Co., Ltd.
Haoyuan Chemexpress Co., Ltd.
MedChemexpress LLC

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