(3N-[(2S,3S)-2-AMINO-3-METHYL-PENTANOYL]-1,3-THIAZOLIDINE) HEMIFUMARATE

P32/98 is a specific, competitive transition-state substrate analog inhibitor of dipeptidyl peptidase IV (DPIV, DPPIV, and CD26). In obese Zucker and lean rats the inhibition of CD26's ability to hydrolyze Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide (GLP-1) lead to an increased secretion of insulin, especially in the obsese Rat, making P32/98 an important tool in diabetic research. P32/ 98 has also been shown to augment YY1-36's ability to enhance renovascular responses to angiotensin II in spontaneoulsy hypertensive rats. Due to CD26's effect on upregultating lymphocyte proliferation P32/98 has been demonstrated to decrease the lymphocyte proliferation.