P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
Description
SKI II is a selective non-lipid inhibitor of SphK(sphingosine kinase) (IC50 = 0.5 M); does not act at ATP-binding site. SKI II displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. SKI II induces apoptosis and inhibits prpliferation in several other tumor cell lines in vitro (IC50 = 0.9-4.6 μM).
