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ChemicalBook > CAS DataBase List > KYNURENIC ACID

KYNURENIC ACID

  • $16.6 - $169
  • Product name:KYNURENIC ACID
  • CAS:492-27-3
  • MF: C10H7NO3
  • MW:189.17
  • EINECS:207-751-5
  • MDL Number:MFCD00006753
  • Synonyms:KYNURENIC ACID;2-Carboxy-4-hydroxyquinoline;4-Hydroxyquinaldinic Acid;NSC 58973;4-Hydroxyquinaldic Acid 4-Hydroxyquinoline-2-carboxylic Acid;4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID FOR;4-keto-1H-quinoline-2-carboxylic acid;4-oxo-1H-quinoline-2-carboxylic acid
Price
  • Brand:Sigma-Aldrich
  • Product number:K3375
  • Product nameKynurenic acid
  • Purity: ≥98%
  • Packaging:5g
  • Price:$132
  • Updated:2020/8/18 13:37:41
  • Buy:Buy
  • Brand:Sigma-Aldrich
  • Product number:67667
  • Product nameKynurenic acid
  • Purity: analytical standard
  • Packaging:50mg
  • Price:$169
  • Updated:2020/8/18 13:37:41
  • Buy:Buy
  • Brand:Sigma-Aldrich
  • Product number:67667
  • Product nameKynurenic acid
  • Purity: analytical standard
  • Packaging:10mg
  • Price:$69
  • Updated:2020/8/18 13:37:41
  • Buy:Buy
  • Brand:TCI Chemical
  • Product number:H0303
  • Product nameKynurenic Acid Hydrate
  • Purity:>98.0%(T)(HPLC)
  • Packaging:1g
  • Price:$47
  • Updated:2021/3/22 18:33:11
  • Buy:Buy
  • Brand:TCI Chemical
  • Product number:H0303
  • Product nameKynurenic Acid Hydrate
  • Purity:>98.0%(T)(HPLC)
  • Packaging:5g
  • Price:$126
  • Updated:2021/3/22 18:33:10
  • Buy:Buy
Properties
  • Melting point:275 °C (dec.)(lit.)
  • Boiling point:324.41°C (rough estimate)
  • Density 1.3175 (rough estimate)
  • refractive index 1.5400 (estimate)
  • storage temp. Sealed in dry,Room Temperature
  • form Off-white to tan powder.
  • pka1.08±0.30(Predicted)
  • Water Solubility 8.92g/L(100 ºC)
  • Merck 14,5327
  • BRN 147451
  • CAS DataBase Reference492-27-3(CAS DataBase Reference)
  • EPA Substance Registry System2-Quinolinecarboxylic acid, 4-hydroxy- (492-27-3)
Safety Information
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Description

Kynurenic acid is a natural metabolite of tryptophan via the kynurenine pathway. It has pronounced effects on neuronal signaling and, thus, impacts diverse neurological systems. Kynurenic acid broadly antagonizes ionotopic glutamate receptors at high micromolar to millimolar concentrations and is used to pharmacologically block the activation of these receptors in vivo or in vitro. In addition, it reportedly has more potent effects at glutamate receptor subunit ζ-1 (Ki = 5.4 μM), GPR35 (EC50 = 39 μM), aryl hydrocarbon receptor (EC50 = 300 nM), and neuronal acetylcholine receptor α-7 (IC50 = 7 μM).


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