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KYNURENIC ACID

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KYNURENIC ACID Basic information
KYNURENIC ACID Chemical Properties
  • Melting point:275 °C (dec.)(lit.)
  • Boiling point:324.41°C (rough estimate)
  • Density 1.3175 (rough estimate)
  • refractive index 1.5400 (estimate)
  • storage temp. Sealed in dry,Room Temperature
  • form Off-white to tan powder.
  • pka1.08±0.30(Predicted)
  • Water Solubility 8.92g/L(100 ºC)
  • Merck 14,5327
  • BRN 147451
  • CAS DataBase Reference492-27-3(CAS DataBase Reference)
  • EPA Substance Registry System2-Quinolinecarboxylic acid, 4-hydroxy- (492-27-3)
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36/37/38
  • Safety Statements 26-36
  • WGK Germany 3
  • RTECS UZ9300000
MSDS
KYNURENIC ACID Usage And Synthesis
  • UsesA product of L-Tryptophan metabolism, possessing neruoactive activity having antiexcitotoxic and anticonvulsant properties.
  • UsesAn antagonist of NMDA and AMPA/kainate receptors
  • Uses
    Kynurenic acid has been used as a constituent in dissection saline solution for embryonic cerebral cortical cells and human primary astrocytes. It has also been used as a medium supplement for murine intestinal epithelial cell line, MODE-K and induced pluripotent stem cell (iPSC)-derived neurons cells.
  • Biological ActivityBroad spectrum EAA antagonist.
  • Biochem/physiol ActionsKynurenic acid (KynA) is a non-selective antagonist of N-methyl-d-aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate receptors. It blocks kainic acid neurotoxicity. Kynurenic acid also blocks nicotinic acetylcholine receptors. It is a by-product of tryptophan catabolic pathway. Kynurenic acid is a neuromodulator and controls the levels of glutamate, dopamine, acetylcholine and α-aminobutyric acid (GABA). KynA controls neuroendocrine functions and altered levels of KynA is a potential marker in depression, schizophrenia Alzheimer′s and Huntington′s diseases. Normal levels of KynA in the brain is crucial for the cognitive function.
  • Purification MethodsCrystallise the acid from absolute EtOH. The methyl ester crystallises from MeOH with m 224-226o. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p2723 1961, Beilstein 22 II 174, 22 III/IV 2245, 22/6 V 280.]
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