H361：Suspected of damaging fertility or the unborn child
Precautionary statements
P201：Obtain special instructions before use.
P202：Do not handle until all safety precautions have been read and understood.
P281：Use personal protective equipment as required.
P308+P313：IF exposed or concerned: Get medical advice/attention.
P405：Store locked up.
P501：Dispose of contents/container to..…
Description
The cytochrome P450 (CYP) isoform CYP17 is also known as steroid 17α-hydroxylase/17,20 lyase because it catalyzes both 17α-hydroxylase and 17,20 lyase reactions in the synthesis of steroids, including androgens, estrogens, glucocorticoids, and mineralocorticoids. Galeterone is a CYP17 inhibitor (IC50 = 300 nM) that has been shown to competitively block synthetic androgen binding (EC50 = 845 nM) and to antagonize the androgen receptor in transcriptional activation assays. Galeterone can inhibit the growth of castration-resistant prostate cancer cells with an IC50 value of 2.9 μM and demonstrates synergy with everolimus or gefitinib for growth inhibition.
