CPCCOEt is a reversible and non-competitive antagonist of mGluR-1 (type 1a mGluR-1 ametabotropic glutamate receptor) activation. Inhibition of the mGluR-1(mGluR-1metabotropic glutamate receptor 1) signal does not affect glutamate binding (IC50=6.5 μM). Studies propose that CPCCOEt inhibits mGluR-1 by preventing the interaction between the agonist-bound extracellular domain and the transmembrane domain. Research shows that CPCCOEt has the ability to improve the tumoricidal effects of cytostatic drugs and that it enhances the climbing fire response in Purkinje neurons, independent of glutamate receptors.
