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ChemicalBook > CAS DataBase List > CALCEIN-AM

CALCEIN-AM

  • $38.5 - $1830
  • Product name:CALCEIN-AM
  • CAS:148504-34-1
  • MF: C46H46N2O23
  • MW:994.86
  • EINECS:200-664-3
  • MDL Number:MFCD00282766
  • Synonyms:3',6'-Di(O-acetyl)-2',7'-bis[N,N-bis(carboxymethyl)aminomethyl]fluoresceintetraacetoxymethylester,DMSOsolution;Calcein AM solution;CALCEIN, AM;CAL-AM;4',5'-Bis(N,N-bis(carboxymethyl)aminomethyl)fluorescein acetoxymethyl ester;Glycine, N,N'-((3',6'-bis(acetyloxy)-3-oxospiro(isobenzofuran-1(3H),9'-(9H)xanthene)-2',7'-diyl)bis(methylene))bis(N-(2-((acetyloxy)methoxy)-2-oxoethyl)-, bis((acetyloxy)methyl) ester;Calcein AcetoxyMethyl Ester;N,N'-[[3',6'-Bis(acetyloxy)-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-2',7'-diyl]bis(Methylene)]bis[N-[2-[(acetyloxy)Methoxy]-2-oxoethyl]glycine 1,1'-Bis[(acetyloxy) Methyl] Ester;NSC 689290
Price
  • Brand:Sigma-Aldrich
  • Product number:206700
  • Product nameCalcein-AM
  • Purity:
  • Packaging:1mg
  • Price:$223.85
  • Updated:2021/3/22 19:32:46
  • Buy:Buy
  • Brand:Sigma-Aldrich
  • Product number:C1359
  • Product nameCalcein AM solution
  • Purity:4mM in DMSO, ≥90% (HPLC), solution
  • Packaging:100ul
  • Price:$255
  • Updated:2020/8/18 13:37:41
  • Buy:Buy
  • Brand:Sigma-Aldrich
  • Product number:C1359
  • Product nameCalcein AM solution
  • Purity:4?mM in DMSO, ≥90% (HPLC), solution
  • Packaging:100 μL
  • Price:$263
  • Updated:2021/3/22 19:32:48
  • Buy:Buy
  • Brand:Sigma-Aldrich
  • Product number:17783
  • Product nameCalcein-AM
  • Purity:BioReagent, suitable for fluorescence, ≥96.0% (HPLC)
  • Packaging:1mg
  • Price:$423
  • Updated:2021/3/22 19:32:46
  • Buy:Buy
  • Brand:Sigma-Aldrich
  • Product number:56496
  • Product nameCalcein-AM
  • Purity:Small Package (20 X 50 μg ), ≥96.0% (HPLC)
  • Packaging:20x50ug
  • Price:$653
  • Updated:2020/8/18 13:37:41
  • Buy:Buy
Properties
  • Melting point:>250℃
  • Boiling point:982.7±65.0 °C(Predicted)
  • Density 1.49±0.1 g/cm3(Predicted)
  • refractive index n20/D 1.479
  • Flash point:85 °C
  • storage temp. -20°C
  • solubility DMSO: soluble10mg/mL, clear, colorless to slightly yellow
  • form powder
  • pka2.66±0.50(Predicted)
  • color Colorless
  • λmax< 300 nm
  • Biological ApplicationsCalcium indicators; zinc indicators; cytotoxicity assays; apoptosis assays; viability assays; labile iron pool assays; chemotaxis probes; cell adhesion probes; mitochondrial probes; P-glycoprotein probes;multi-drug resistance probes;treating atherosclerosis,cancer;ischemic disease
Safety Information
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Description

Calcein AM is a cell-permeable dye that, upon entering live cells, is cleaved by intracellular esterases, leaving membrane-impermeant calcein , a fluorescent indicator with absorption and emission maxima of 494 and 517 nm, respectively. It can be used as an indicator of cell viability, cell-cell communication, cytotoxicity, or changes in intracellular calcium, fluoride, iron, or mercury. As calcein is a substrate for multidrug resistance-associated protein 1 (MRP1) and multidrug resistance protein 3 (MDR3, P-glycoprotein 3), calcein AM is used to study these proteins and their regulation.


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