Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 5 mg/ml with warming).
form
Solid
pka
5.20±0.50(Predicted)
color
White
Stability
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Safety Information
Symbol(GHS)
Signal word
Danger
Hazard statements
H301：Toxic if swalloed
Precautionary statements
P264：Wash hands thoroughly after handling.
P264：Wash skin thouroughly after handling.
P270：Do not eat, drink or smoke when using this product.
P301+P310：IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405：Store locked up.
P501：Dispose of contents/container to..…
Description
Teriflunomide (Aubagio®), also known as A77 1726, is an immunosupressant marketed by Sanofi for
the teatment of multiple sclerosis (MS). Teriflunomide is the active metabolite of leflunomide, used
for treatment of patients diagnosed with rheumatoid arthritis, and therefore simultaneously can be used
as a treatment for rheumatoid arthritis.Teriflunomide acts as an inhibitor of the mitochondrial
enzyme dihydrorotate dehydrogenase, inhibiting pyrimidine formation, and resulting in reduced
B and T cell proliferation.
