2'-O-метилцитидин
- английское имя2'-O-Methylcytidine
- CAS №2140-72-9
- CBNumberCB9324099
- ФормулаC10H15N3O5
- мольный вес257.24
- EINECS2017-001-1
- номер MDLMFCD11519076
- файл Mol2140-72-9.mol
химическое свойство
| Температура плавления | 252-253 C |
| Температура кипения | 506.0±60.0 °C(Predicted) |
| плотность | 1.68±0.1 g/cm3(Predicted) |
| температура хранения | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| растворимость | Soluble in DMSO. |
| пка | 13.37±0.70(Predicted) |
| форма | Powder |
| цвет | White to Off-white |
| РН | 4.2 |
| λмакс | 281 (pH 1)；273 (EtOH) |
| InChI | InChI=1S/C10H15N3O5/c1-17-8-7(15)5(4-14)18-9(8)13-3-2-6(11)12-10(13)16/h2-3,5,7-9,14-15H,4H2,1H3,(H2,11,12,16)/t5-,7-,8-,9-/m1/s1 |
| ИнЧИКей | RFCQJGFZUQFYRF-ZOQUXTDFSA-N |
| SMILES | OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](OC)[C@@H]1O |
| Справочник по базе данных CAS | 2140-72-9(CAS DataBase Reference) |
| FDA UNII | 5XD9IH2G27 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
| Коды опасности | Xi |
| Заявления о рисках | 36/37/38 |
| Заявления о безопасности | 26-36-24/25 |
| WGK Германия | 3 |
| кода HS | 29349990 |
2'-O-метилцитидин химические свойства, назначение, производство
Описание
2'-O-Methylcytidine is a nucleoside with a hydroxyl group on the 2' carbon, making it an effective viral replication inhibitor. 2'-O-Methylcytidine is also metabolized by nucleotide salvage pathways and may be able to bind to the response element on DNA, which could inhibit protein synthesis in cancer cells. It is an inhibitor of hepatitis C virus (HCV) non-structural protein 5B (NS5B; IC50 = 3.8 μM). It inhibits HCV replication in a replicon assay (IC50 = 21.2 μM).Химические свойства
White powderИспользование
2'-O-Methylcytidine is used in the preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.2'-O-метилцитидин запасные части и сырье
запасной предмет
2'-O-метилцитидин поставщик
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