ТРИФЕНИЛФОСФАТ
- английское имяTriphenyl phosphate
- CAS №115-86-6
- CBNumberCB9233809
- ФормулаC18H15O4P
- мольный вес326.28
- EINECS204-112-2
- номер MDLMFCD00003031
- файл Mol115-86-6.mol
химическое свойство
| Температура плавления | 48-50 °C (lit.) |
| Температура кипения | 244 °C/10 mmHg (lit.) |
| плотность | 1.2055 |
| плотность пара | 11.3 (vs air) |
| давление пара | 1.3 mm Hg ( 200 °C) |
| показатель преломления | 1.563 |
| Fp | 435 °F |
| температура хранения | Store below +30°C. |
| растворимость | H2O: soluble0.0019g/L at 20°C |
| форма | Crystalline Flakes |
| цвет | White |
| Запах | Odorless |
| Вязкость | 11mm2/s |
| Растворимость в воде | insoluble |
| Мерк | 14,9742 |
| БРН | 1888236 |
| констант закона Генри | 5.88 at 20 °C (approximate - calculated from water solubility and vapor pressure) |
| Пределы воздействия | TLV-TWA air 3 mg/m3 (ACGIH, OSHA, and NIOSH). |
| Стабильность | Stable. |
| ИнЧИКей | XZZNDPSIHUTMOC-UHFFFAOYSA-N |
| LogP | 4.6 at 20℃ |
| Непрямые добавки, используемые в веществах, контактирующих с пищевыми продуктами | TRIPHENYL PHOSPHATE |
| FDA 21 CFR | 175.105 |
| Справочник по базе данных CAS | 115-86-6(CAS DataBase Reference) |
| Рейтинг продуктов питания EWG | 5 |
| FDA UNII | YZE19Z66EA |
| Справочник по химии NIST | Triphenylphosphate(115-86-6) |
| Система регистрации веществ EPA | Triphenyl phosphate (115-86-6) |
больше
| Коды опасности | Xn,N,F,Xi | |||||||||
| Заявления о рисках | 22-38-40-48/20/22-50/53-52/53-36/37/38-67-66-36-11-51/53 | |||||||||
| Заявления о безопасности | 36/37-61-60-24/25-22-36-26-16-24-9 | |||||||||
| РИДАДР | UN 3077 9/PG 3 | |||||||||
| OEB | B | |||||||||
| OEL | TWA: 3 mg/m3 | |||||||||
| WGK Германия | 2 | |||||||||
| RTECS | TC8400000 | |||||||||
| Температура самовоспламенения | >500 °C | |||||||||
| TSCA | Yes | |||||||||
| Класс опасности | 9 | |||||||||
| Группа упаковки | III | |||||||||
| кода HS | 29190010 | |||||||||
| Банк данных об опасных веществах | 115-86-6(Hazardous Substances Data) | |||||||||
| Токсичность | LD50 orally in Rabbit: 3500 mg/kg LD50 dermal Rabbit > 7900 mg/kg | |||||||||
| ИДЛА | 1,000 mg/m3 | |||||||||
| NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H315：При попадании на кожу вызывает раздражение.
H319：При попадании в глаза вызывает выраженное раздражение.
H302：Вредно при проглатывании.
H372：Поражает органы в результате многократного или продолжительного воздействия.
H351：Предполагается, что данное вещество вызывает раковые заболевания.
H336：Может вызывать сонливость или головокружение.
H361d：Предполагается, что данное вещество может отрицательно повлиять на неродившегося ребенка.
H331：Токсично при вдыхании.
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оператор предупредительных мер
P201：Беречь от тепла, горячих поверхностей, искр, открытого огня и других источников воспламенения. Не курить.
P301+P312：ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии.
P302+P352：ПРИ ПОПАДАНИИ НА КОЖУ: Промыть большим количеством воды.
P304+P340+P311：ПРИ ВДЫХАНИИ: Свежий воздух, покой. Обратиться за медицинской помощью.
P305+P351+P338：ПРИ ПОПАДАНИИ В ГЛАЗА: Осторожно промыть глаза водой в течение нескольких минут. Снять контактные линзы, если Вы ими пользуетесь и если это легко сделать. Продолжить промывание глаз.
P308+P313：ПРИ подозрении на возможность воздействия обратиться за медицинской помощью.
ТРИФЕНИЛФОСФАТ химические свойства, назначение, производство
Химические свойства
Triphenyl phosphate (TPP) is a colorless crystalline powder with a faint, phenol-like odor. Triphenyl phosphate is practically insoluble in water at 1.9 × 10 7 mg/l at 24 °C (Yalkowsky et al., 2010). It is very soluble in carbon tetrachloride (Haynes, 2010) and is soluble in most lacquers, solvents, thinners, and oils, as well as in alcohol, benzene, ether, chloroform, and acetone (Lewis, 1996). It begins to decompose at about 600 °C in inert gas, and in a large excess of air, complete combustion to carbon dioxide occurs in the range 800–900 °C (Lhomme et al., 1984). Hydrolysis of TPP occurs very slowly in acidic or neutral solutions, but occurs rapidly in alkaline solutions (Barnard et al., 1966).Использование
Triphenyl phosphate is known as a product with manifold fields of applications regarding its qualities in particular as a flame retardant. One primary use is as a flame retardant in phenolic- and phenylene oxide-based resins for the manufacture of electrical and automobile components, for auto upholstery, and as a nonflammable plasticizer in cellulose acetate for photographic films. It has also been used to impregnate roofing paper. Triphenyl phosphate occurs as a plasticizer in various lacquers and varnishes (O'Neil, 2006), and as a component of lubricating oil and hydraulic fluids (ACGIH, 2012).Определение
ChEBI: Triphenyl phosphate is an aryl phosphate resulting from the formal condensation of phosphoric acid with 3 mol eq. of phenol. It has a role as a flame retardant and a plasticiser. It is functionally related to a phenol.прикладной
Triphenyl Phosphate is used in the insecticidal composition. It is also use in hydraulic liquids, and adhesives, inks, coatings, as a plasticizer in lacquers and varnishes, and as a substitute for camphor in celluloid materials to make the latter stable and fireproof.Подготовка
Triphenyl phosphate is prepared by reacting phosphorus pentoxide and phenol (Budavari, 2001), or by reacting phosphorus oxychloride and phenol (Snyder, 1990). On a larger scale phosphorus oxychloride and phenol are reacted in an esterification tank with heating. The HCL formed is trapped and condensed, while the crude triphenyl phosphate runs into a large tank where it is purified.Профиль реактивности
Organophosphates, such as Triphenyl phosphate, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.Опасность
Toxic by inhalation. Cholinesterase inhibitor. Questionable carcinogen.Влияние на здоровье
Non-industrial:An allergic reaction in a 67-year old woman to spectacle frames containing triphenyl phosphate was reported. Patch tests with analytical grade triphenyl phosphate in that individual indicated a reaction at concentrations as low as 0.05%. This observation was confirmed in another male patient (Carlsen et al 1986).
Industrial:
Occupational exposure of men engaged in manufacturing triphenyl phosphate produced a statistically significant reduction in erythrocyte acetylcholinesterase activity and plasma cholinesterase activity. There was no evidence of adverse clinical effects in men exposed to triphenyl phosphate for as long as 10 years. Exposure was to triphenyl phosphate mist, vapor, and dust at a weighted average air concentration of 3.5 mg/m3 (Sutton et al 1960).
Пожароопасность
Noncombustible solid. Incompatibility— none.Профиль безопасности
Poison by subcutaneous route. Moderately toxic by ingestion. Absorbed slowly, particularly by skin contact. Not a potent cholinesterase inhibitor. Combustible when exposed to heat or flame. To fight fire, use CO2, dry chemical. When heated to decomposition it emits toxic fumes of POx. See also TRITOLYL PHOSPHATE.Возможный контакт
Triphenyl phosphate is used to impregnate roofing paper and as a fire-resistant plasticizer in plastics; for cellulose esters in lacquers and varnishes. Used in making adhesives, gasoline additives; flotation agents; insecticides, surfactants, antioxidants, and stabilizers. A substitute for camphor.Экологическая судьба
Chemical/Physical. When an aqueous solution containing triphenyl phosphate (0.1 mg/L) and chlorine (3 to 1,000 mg/L) was stirred in the dark at 20 °C for 24 h, the benzene ring was substituted with one to three chlorine atoms (Ishikawa and Baba, 1988). The reported hydrolysis half-lives at pH values of 8.2 and 9.5 were 7.5 and 1.3 d, respectively (Howard and Doe, 1979).Decomposes at temperatures greater than 410 °C (Dobry and Keller, 1957)
Метаболизм
Rat liver microsomal enzymes degraded triphenyl phosphate in the presence of NADPH, but also in the absence of NADPH. The product of incubation was diphenyl phosphate. It was clear that the reaction was cytochrome P-450-linked since the reaction was inhibited by carbon monoxide (Sasaki et al 1984). Goldfish liver microsomes metabolized only about 10% of triphenyl phosphate (Sasaki et al 1985). Houseflies treated with triphenyl phosphate were analyzed after 24 h and the presence of diphenyl p-hydroxyphenyl phosphate was confirmed (Eto et al 1975).Перевозки
UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.Методы очистки
Crystallise the phosphate from EtOH or pet ether (b 60-80o)/EtOH. [Cox & Westheimer J Am Chem Soc 80 5441 1958, Krishnakumar & Sharma Synthesis 558 1983, Cherbuliez in Organo Phosphorus Compounds (Kosolapoff & Maier eds) Wiley Vol 6 pp 211-577 1973, Beilstein 6 III 658, 6 IV 720.]Оценка токсичности
Triphenyl phosphate(TPP) is neurotoxic, causing paralysis at high dosages. Like tri-o-cresyl phosphate (TOCP), it is a cholinesterase inhibitor. The acute oral toxicity is low. The acute toxicity via subcutaneous administration is low to moderate. The toxic symptoms from high dosages in test animals were tremor, diarrhea, muscle weakness, and paralysis.LD50 value, oral (mice): 1320 mg/kg
LD50 value, subcutaneous (cats): 100 mg/kg
Cleveland et al. (1986) investigated the acute and chronic toxicity to various species of freshwater fish of phosphate ester compounds containing TPP. The adverse toxic effects occurred at exposure concentrations of 0.38–1.0 mg/L.
Несовместимости
Incompatible with strong oxidizers; strong acids; nitrates may cause fire or explosions. Phosphates are incompatible with antimony pentachloride, magnesium, silver nitrate, zinc acetate.Утилизация отходов
Incinerate in furnace equipped with alkaline scrubber.ТРИФЕНИЛФОСФАТ запасные части и сырье
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