Тетраметилтиурам дисульфид
- английское имяTetramethylthiuram Disulfide
- CAS №137-26-8
- CBNumberCB9218792
- ФормулаC6H12N2S4
- мольный вес240.43
- EINECS205-286-2
- номер MDLMFCD00008325
- файл Mol137-26-8.mol
химическое свойство
| Температура плавления | 156-158 °C(lit.) |
| Температура кипения | 129 °C (20 mmHg) |
| плотность | 1.43 |
| давление пара | 8 x 10-6 mmHg at 20 °C (NIOSH, 1997) |
| показатель преломления | 1.5500 (estimate) |
| Fp | 89°C |
| температура хранения | under inert gas (argon) |
| растворимость | 0.0184g/l |
| форма | solid |
| пка | 0.87±0.50(Predicted) |
| Растворимость в воде | 16.5 mg/L (20 ºC) |
| Мерк | 14,9371 |
| БРН | 1725821 |
| Пределы воздействия | NIOSH REL: TWA 0.5 mg/m3, IDLH 100 mg/m3; OSHA PEL: 0.5 mg/m3; ACGIH TLV: TWA 5 mg/m3. |
| ИнЧИКей | KUAZQDVKQLNFPE-UHFFFAOYSA-N |
| LogP | 1.730 |
| Справочник по базе данных CAS | 137-26-8(CAS DataBase Reference) |
| Непрямые добавки, используемые в веществах, контактирующих с пищевыми продуктами | THIRAM |
| FDA 21 CFR | 175.105 |
| Рейтинг продуктов питания EWG | 5-8 |
| FDA UNII | 0D771IS0FH |
| Код УВД | P03AA05 |
| МАИР | 3 (Vol. Sup 7, 53) 1991 |
| Справочник по химии NIST | Thiram(137-26-8) |
| Система регистрации веществ EPA | Thiram (137-26-8) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
больше
| Коды опасности | Xn,N | |||||||||
| Заявления о рисках | 20/22-36/38-43-48/22-50/53 | |||||||||
| Заявления о безопасности | 26-36/37-60-61 | |||||||||
| РИДАДР | UN 2771/2811 | |||||||||
| OEB | B | |||||||||
| OEL | TWA: 5 mg/m3 | |||||||||
| WGK Германия | 3 | |||||||||
| RTECS | JO1400000 | |||||||||
| Температура самовоспламенения | 316 °F | |||||||||
| TSCA | Yes | |||||||||
| Класс опасности | 9 | |||||||||
| Группа упаковки | III | |||||||||
| кода HS | 29303000 | |||||||||
| Банк данных об опасных веществах | 137-26-8(Hazardous Substances Data) | |||||||||
| Токсичность | LD50 orally in rats: 640 mg/kg (Gaines) | |||||||||
| ИДЛА | 100 mg/m3 | |||||||||
| NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
предупреждение
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вредная бумага
H315：При попадании на кожу вызывает раздражение.
H319：При попадании в глаза вызывает выраженное раздражение.
H317：При контакте с кожей может вызывать аллергическую реакцию.
H302+H332：Вредно при проглатывании или при вдыхании.
H410：Чрезвычайно токсично для водных организмов с долгосрочными последствиями.
H373：Может поражать органы (Нервная система) в результате многократного или продолжительного воздействия при вдыхании.
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оператор предупредительных мер
P273：Избегать попадания в окружающую среду.
P280：Использовать перчатки/ средства защиты глаз/ лица.
P301+P312：ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии.
P302+P352：ПРИ ПОПАДАНИИ НА КОЖУ: Промыть большим количеством воды.
P304+P340+P312：ПРИ ВДЫХАНИИ: Свежий воздух, покой. Обратиться за медицинской помощью при плохом самочувствии.
P314：В случае плохого самочувствия обратиться к врачу.
Тетраметилтиурам дисульфид химические свойства, назначение, производство
Описание
Tetramethylthiuram disulfide is a rubber chemieal, an accelerator of vulcanization. It represents the most commonly positive allergen contained in the "thiuram mix". The most frequent occupational categories are the metal industry, homemakers, health services and laboratories, building industries, and shoemakers.Химические свойства
white to almost white powderФизические свойства
Colorless to white to cream-colored crystals. May darken on exposure to air or light.Использование
Tetramethylthiuram disulfide is used as fungicide; bacteriostat; pesticide; rubber vulcanization accelerator; scabicide; seed disinfectant; animal repellent; insecticide; lube-oil additive; wood preservative; in antiseptic sprays; in the blending of lubrieant oils; used against Botrytis, rusts and downy mildews; seed dressing against "damping off' and verticillium wilt; ethanol antagonist and deterrent in mixtures of the methyl, ethyl, propyl, and butyl derivatives; antioxidant in polyolefin plastics; peptizing agent in polysulphide elastomers; in soaps and rodent repellents; nut, fruit, and mushroom disinfectant.Определение
ChEBI: An organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid. It is widely used as a fungicidal seed treatment.Общее описание
A liquid solution of a white crystalline solid. Primary hazard is to the environment. Immediate steps should be taken to limit spread to the environment. Easily penetrates the soil to contaminates groundwater and waterways.Реакции воздуха и воды
Insoluble in water. Decomposes in acidic media to give toxic products. Decomposes to an extent on prolonged exposure to heat, air or moisture.Профиль реактивности
TMTD is incompatible with oxidizing materials and strong acids. Also incompatible with strong alkalis and nitrating agents .Опасность
Toxic by ingestion and inhalation, irritant to skin and eyes. Body weight and hematologic effects. Questionable carcinogen.Угроза здоровью
Inhalation of dust may cause respiratory irritation. Liquid irritates eyes and skin and may cause allergic eczema in sensitive individuals. Ingestion causes nausea, vomiting, and diarrhea, all of which may be persistent; paralysis may develop.Пожароопасность
Special Hazards of Combustion Products: Toxic and irritating oxides of sulfur are formed. Carbon disulfide may be formed from unburned material.Сельскохозяйственное использование
Fungicide, Rodenticide: Thiram is used as a fungicide to prevent crop damage in the field and to prevent crops from deterioration in storage or transport. Thiram is also used as a seed, nut, fruit, and mushroom disinfectant from a variety of fungal diseases. In addition, it is used as an animal repellent to protect fruit trees and ornamentals from damage by rabbits, rodents, and deer. Thiram has been used in the treatment of human scabies, as a sun screen, and as a bactericide applied directly to the skin or incorporated into soap. Thiram is used as a rubber accelerator and vulcanizer and as a bacteriostat for edible oils and fats. It is also used as a rodent repellent, wood preservative, and may be used in the blending of lubricant oils. Registered for use in EU countries. Registered for use in the U.S.Контактные аллергены
TITD is a rubber vulcanization acceleratorПрофиль безопасности
Poison by ingestion and intraperitoneal routes. Questionable carcinogen with experimental tumorigenic and teratogenic data. Other experimental reproductive effects. Mutation data reported, Affects human pulmonary system. A rmld allergen and irritant. Acute poisoning in experimental animals produced liver, hdney, and brain damage. Dangerous in a fire; see NITROGEN MONOXIDE and SULFUR DIOXIDE.Возможный контакт
Thiram is a dithiocarbamate. Some thiurams have been used as rubber components: thiram is used as a rubber accelerator and vulcanizer; a seed, nut, fruit, and mushroom disinfectant; a bacteriostat for edible oils and fats; and as an ingredient in suntan and antiseptic sprays and soaps. It is also used as a fungicide, rodent repellent; wood preservative; and may be used in the blending of lubricant oils.Канцерогенность
Thiram also was not carcinogenic in rats by gavage or in mice by single subcutaneous injection. In skin painting studies in mice thiram had tumor-initiating and -promoting activity but was not a complete carcinogen.Thiram was genotoxic to insects, plants, fungi, and bacteria: it induced sister chromatid exchange and unscheduled DNA synthesis in cultured human cells. Despite established genotoxicity in vitro, it showed no clastogenic and/or aneugenic activity in vivo after oral administration to mice at the maximum tolerated dose.
Метаболический путь
Dialkyldithiocarbamates chelate copper and inhibit pyruvate dehydrogenase. It is likely that the mode of action of chelators is principally through their effect on lipoamide containing dehydrogenases (Corbett et al., 1984). Thiram generates dimethyldithiocarbamic acid by being cleaved in acidic conditions and in biological media. The acid is conjugated with glucose and alanine in plants and with glucuronic acid in mammals. Dimethyldithiocarbamic acid is further degraded to dimethylamine and CS2. An extensive review of the properties of dithiocarbamate pesticides was published by the World Health Organisation (WHO, 1988) from which much of the following information is taken.Перевозки
UN2771 Thiocarbamate pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.Методы очистки
Crystallise thiram (three times) from boiling CHCl3, then recrystallise it from boiling CHCl3 by adding EtOH dropwise to initiate crystallisation, and allow it to cool. Finally it is precipitated from cold CHCl3 by adding EtOH (which retains the monosulfide in solution). [Ferington & Tobolsky J Am Chem Soc 77 4510 1955, Beilstein 4 IV 242.]Несовместимости
Dust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine,fluorine, etc.); contact may cause fires or explosions. Keep away from strong alkaline materials, strong acids, strong bases and nitrating agents.Утилизация отходов
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Thiram can be dissolved in alcohol or other flammable solvent and burned in an incinerator with an afterburner and scrubber.Тетраметилтиурам дисульфид запасные части и сырье
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