Ксилазин
- английское имяXylazine
- CAS №7361-61-7
- CBNumberCB8130978
- ФормулаC12H16N2S
- мольный вес220.33
- EINECS230-902-1
- номер MDLMFCD00057908
- файл Mol7361-61-7.mol
химическое свойство
| Температура плавления | 140 C |
| Температура кипения | 334.2±52.0 °C(Predicted) |
| плотность | 1.0905 (rough estimate) |
| показатель преломления | 1.5700 (estimate) |
| температура хранения | -20°C |
| растворимость | Soluble in methanol at 50mg/ml. Also soluble in dilute acid solutions. |
| форма | Powder |
| пка | 7.67±0.20(Predicted) |
| InChI | InChI=1S/C12H16N2S/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12/h3,5-6H,4,7-8H2,1-2H3,(H,13,14) |
| ИнЧИКей | BPICBUSOMSTKRF-UHFFFAOYSA-N |
| SMILES | S1CCCN=C1NC1=C(C)C=CC=C1C |
| Справочник по базе данных CAS | 7361-61-7(CAS DataBase Reference) |
| FDA UNII | 2KFG9TP5V8 |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
| Коды опасности | T,Xi | |||||||||
| Заявления о рисках | 25-36/37/38 | |||||||||
| Заявления о безопасности | 45-37/39-26 | |||||||||
| РИДАДР | UN 2811 6.1/PG 3 | |||||||||
| WGK Германия | 3 | |||||||||
| RTECS | XJ0776300 | |||||||||
| Класс опасности | 6.1 | |||||||||
| кода HS | 2934990002 | |||||||||
| Токсичность | LD50 in mice (mg/kg): 43 i.v.; 121 s.c.; 240 orally; LD50 in rats (mg/kg): 130 orally (Sagner) | |||||||||
| NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H301：Токсично при проглатывании.
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оператор предупредительных мер
P301+P330+P331+P310：ПРИ ПРОГЛАТЫВАНИИ: Прополоскать рот. Не вызывать рвоту! Немедленно обратиться за медицинской помощью.
Ксилазин химические свойства, назначение, производство
Описание
Xylazine is an agonist of α2-adrenergic receptors (Ki = 194 nM). It is an analog of clonidine, an α2-adrenergic receptor agonist used to reduce blood pressure. Xylazine is used for sedation, anesthesia, and analgesia in non-human mammals. This product is also available as an analytical reference standard .Использование
Xylazine is an α2 class of adrenergic receptor agonist. Xylazine is a clonidine analoque that acts on presynaptic and postsynaptic receptors as an a 2-adrenergic agonist.Общее описание
Xylazine is soluble in methanol (50 mg/ml), yielding a clear, colorless solution. It is also soluble in dilute HCl acid and in chloroform. Xylazine is practically insoluble in water and in alkali solutions.Механизм действия
Xylazine is marketed as its hydrochloride salt as Rompun (100 mg/mL) and Anased (20 mg/mL) injectable solutions for intravenous administration to horses and dogs, respectively. The actions of xylazine may be reversed by the administration of yohimbine, an indolalkylamine alkaloid, that blocks those α2- adrenoreceptors that are stimulated by xylazine.Побочные эффекты
High doses of Xylazine can cause dizziness, vomiting, high blood sugar, blurry vision and even overdose deaths. If you inject xylazine into your body, you also may develop skin ulcers and severe wounds that can spread and worsen quickly. Xylazine can lead to depression of the central nervous system along with other adverse effects. As for animals, they may show profound salivation following an injection with xylazine. Other adverse effects for dogs and cats include: muscle tremors, bradycardia with AV-block, hypotension, reduced respiratory rate, movement in response to strong auditory stimuli, and increased urination in cats.Профиль безопасности
Poison by ingestion, subcutaneous, and intravenous routes. Human systemic effects: change in motor activity, fall in blood pressure, miosis, pleural thickening, pulse rate decrease, somnolence. When heated to decomposition it emits very toxic fumes of NOx and SOx.