Сульфагуанидин

Химические свойства

white powder

Использование

Sulfaguanidine is a sulfonamide based antibiotic drug with potential application in veterinary medicine.

Всемирная организация здравоохранения(ВОЗ)

Sulfaguanidine, a sulfonamide anti-infective agent, was introduced in 1941 for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. The sulfonamides are known to cause serious adverse effects such as renal toxicity sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Although sulfaguanidine, which is poorly absorbed from the gastrointestinal tract, is no longer recommended in some countries, it continues to be used in others for the treatment of local intestinal infections, including bacterial dysentery, and for preoperative bowel preparation.

Фармацевтические приложения

1-Sulfanilylguanidine. A poorly absorbed compound, less potent than succinylsulfathiazole but with similar uses. Blood concentrations of 15–40 mg/L have been found after single doses of 1–7 g. Excretion in the urine is rapid.

Профиль безопасности

Moderately toxic by intraperitoneal route. An experimental teratogen. Other experimental reproductive effects. See also SULFONATES. When heated to decomposition it emits very toxic fumes of SO, and NO,.

Методы очистки

Crystallise the antibacterial from hot water (7mL/g). [Beilstein 14 III 1970, 14 IV 2668.]