DL-Glutethimide
- русский язык имя
- английское имяDL-Glutethimide
- CAS №77-21-4
- CBNumberCB6399670
- ФормулаC13H15NO2
- мольный вес217.26
- EINECS201-012-0
- номер MDLMFCD00056091
- файл Mol77-21-4.mol
химическое свойство
| Температура плавления | 84°C |
| Температура кипения | 357.82°C (rough estimate) |
| плотность | 1.0960 (rough estimate) |
| показатель преломления | 1.5300 (estimate) |
| Fp | 9℃ |
| температура хранения | -20°C |
| растворимость | Chloroform (Slightly), Methanol (Slightly) |
| форма | Solid |
| пка | pKa 11.8 (Uncertain) |
| цвет | Off-White to Light Beige |
| Растворимость в воде | 0.95g/L(27 ºC) |
| Справочник по базе данных CAS | 77-21-4(CAS DataBase Reference) |
| Рейтинг продуктов питания EWG | 1 |
| FDA UNII | C8I4BVN78E |
| Код УВД | N05CE01 |
| Справочник по химии NIST | Glutethimide(77-21-4) |
| Коды опасности | Xn,T,F |
| Заявления о рисках | 22-39/23/24/25-23/24/25-11 |
| Заявления о безопасности | 36-45-36/37-16-7 |
| РИДАДР | 3249 |
| WGK Германия | 1 |
| RTECS | MA4725000 |
| Класс опасности | 6.1(b) |
| Группа упаковки | III |
| кода HS | 29251200 |
| Банк данных об опасных веществах | 77-21-4(Hazardous Substances Data) |
| Токсичность | Glutethimide, and a structurally similar compound methyprylon, has been used occasionally as a sedative-hypnotic, although glutethimide’s use for longer than 3 days is not recommended and it is rarely, if ever, prescribed today. Glutethimide causes a skin rash in nearly 10% of those using it, and although it was once thought to produce less respiratory depression than the barbiturates its overdose fatality record is not good. Much of the drug’s action can be attributed to 4-hydroxyglutethimide, which is more than twice as potent and has a long half-life. Like many other sedativehypnotics, abrupt withdrawal after chronic use or abuse resembles that of ethanol or the barbiturates and must be managed accordingly. |
рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H301+H311+H331：Токсично при проглатывании, при контакте с кожей или при вдыхании.
H225：Легковоспламеняющаяся жидкость. Пары образуют с воздухом взрывоопасные смеси.
H370：Поражает органы (Глаза) в результате однократного воздействия.
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оператор предупредительных мер
P210：Беречь от тепла, горячих поверхностей, искр, открытого огня и других источников воспламенения. Не курить.
P260：Не вдыхать газ/ пары/ пыль/ аэрозоли/ дым/ туман.
P280：Использовать перчатки/ средства защиты глаз/ лица.
P301+P310：ПРИ ПРОГЛАТЫВАНИИ: Немедленно обратиться за медицинской помощью. Прополоскать рот.
P311：Обратиться за медицинской помощью.
DL-Glutethimide химические свойства, назначение, производство
Химические свойства
White, crystalline powder.Saturated solution is slightly acid. Freely soluble in acetone, ethyl acetate, and chloroform; soluble in ethanol and methanol; practically insoluble in water.Использование
Sedative-hypnotic.Всемирная организация здравоохранения(ВОЗ)
Glutethimide, a piperidine derivative, was introduced in 1955 for use as a sedative-hypnotic drug. Its addiction liability and severity of withdrawal symptoms are equal to those of the barbiturates and it is controlled under Schedule III of the 1971 Convention on Psychotropic Substances. (Reference: (UNCPS3) United Nations Convention on Psychotropic Substances (III), , , 1971)Общее описание
Glutethimide, 2-ethyl-2-phenylglutarimide(Doriden), is one of the most active nonbarbituratehypnotics that is structurally similar to the barbiturates,especially phenobarbital. Because of glutethimide’s lowaqueous solubility, its dissolution and absorption from theGI track is somewhat erratic. Consistent with its highlipophilicity, it undergoes extensive oxidative metabolismin the liver with a half-life of approximately 10 hours.Glutethimide is used as a racemic mixture with the (+)enantiomer being primarily metabolized on the glutarimidering and the (—) enantiomer on the phenyl ring. The productof metabolic detoxification is excreted after conjugationwith glucuronic acid at the hydroxyl group. The drug is anenzyme inducer. In the therapeutic dosage range, adverse effectstend to be infrequent. Toxic effects in overdose are assevere as, and possibly more troublesome than, those of thebarbiturates.Опасность
Manufacture and use controlled by law.Профиль безопасности
Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: pupillary dilation, ataxia, somnolence, coma, and blood pressure depression. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. Caution: May be habit forming. This is a controlled substance (depressant) listed in the US. Code of Federal Regulations, Title 21 Part 1308.13 (1985)Методы очистки
Crystallise glutethimide from diethyl ether or ethyl acetate/pet ether. It has m 91-92o (from aqueous EtOH), 87-87.5o (from Et2O/pet ether), 84-87o (from isopropanol), and 83-84o (from Et2O). [Penprase & Biles J Am Pharm Assoc 47 523 1958, Hofmann et al. Helv Chim Acta 40 387, 393 1957, Beilstein 21 III/IV 5493.] The R(+)-enantomer crystallises from EtOAc/pet ether with m 103-104o, and [ ] 20+184o (c 1,