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Тетракис (трифенилфосфин) палладий
- английское имяTetrakis(triphenylphosphine)palladium
- CAS №14221-01-3
- CBNumberCB6163934
- ФормулаC72H60P4Pd
- мольный вес1155.561844
- EINECS238-086-9
- номер MDLMFCD00010012
- файл Mol14221-01-3.mol
химическое свойство
Температура плавления | 103-107 °C |
давление пара | 0Pa at 25℃ |
температура хранения | 2-8°C |
растворимость | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
форма | Fine Powder or Platelets |
цвет | Bright yellow to khaki |
Растворимость в воде | insoluble |
Гидролитическая чувствительность | 7: reacts slowly with moisture/water |
Чувствительный | Light Sensitive/Air Sensitive |
БРН | 6704828 |
Стабильность | Light Sensitive, Moisture Sensitive |
ИнЧИКей | NANALCPCPBPJAB-UHFFFAOYSA-N |
LogP | 5.69 at 20℃ |
Справочник по базе данных CAS | 14221-01-3(CAS DataBase Reference) |
FDA UNII | N9O1RWZ93J |
Система регистрации веществ EPA | Palladium, tetrakis(triphenylphosphine)-, (T-4)- (14221-01-3) |
Коды опасности | Xi,Xn | |||||||||
Заявления о рисках | 20/22-40-36/37/38 | |||||||||
Заявления о безопасности | 22-24/25-36/37-37/39-26 | |||||||||
WGK Германия | 3 | |||||||||
F | 8-10-23 | |||||||||
Примечание об опасности | Air sensitive/Light sensitive/Irritant | |||||||||
TSCA | No | |||||||||
Класс опасности | MOISTURE SENSITIVE, STORED UNDER ARGON | |||||||||
кода HS | 28439090 | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
предупреждение
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вредная бумага
H302:Вредно при проглатывании.
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оператор предупредительных мер
P264:После работы тщательно вымыть кожу.
P270:При использовании продукции не курить, не пить, не принимать пищу.
P301+P312:ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии.
P501:Удалить содержимое/ контейнер на утвержденных станциях утилизации отходов.
Тетракис (трифенилфосфин) палладий химические свойства, назначение, производство
Химические свойства
yellow crystalsИспользование
Tetrakis(triphenylphosphine)palladium(0) is widely used as a catalyst for palladium-catalyzed coupling reactions.прикладной
Palladium-Catalyzed Three-Component Reaction for the Synthesis of Imidazolidinones.![Palladium-Catalyzed Three-Component Reaction for the Synthesis of Imidazolidinones.gif Palladium-Catalyzed Three-Component Reaction for the Synthesis of Imidazolidinones.gif](/NewsImg/2023-04-25/6381801467244134321816868.jpg)
Once the Schlenk tube containing K2CO3 (55 mg, 0.40 mmol) is flamed, dried, and filled with argon, Tetrakis(triphenylphosphine)palladium (12 mg, 0.010 mmol), PMB-protected 2,3-allenylamine (37 mg, 0.20 mmol), iodobenzene (58 mg, 0.28 mmol), phenyl isocyanate (36 mg, 0.30 mmol), and CH3CN (4 mL) are added sequentially. The resulting solution is heated to and stirred at 70°C. When the reaction is completed as monitored by TLC, the solvent is evaporated under reduced pressure, and the residue is purified by chromatography on silica gel (petroleum ether : ethyl acetate = 7:1) to afford the corresponding imidazolidione (72 mg, Y. 96%) as an oil.
Реакции
- Catalyst for Suzuki coupling of chiral secondary organoboronic esters.
- Palladium-catalyzed SNAr reactions for the synthesis of heteroaryl ethers.
- Catalyst for cross-coupling of a-diazocarbonyl compouns with arylboronic acids.
- Diastereoselective synthesis of trans-1,2-diazetidines.
- Palladium-catalyzed alkynyl iminium ion cyclization.
- Widely used reagent in a variety of transformations including Heck arylation, enyne and diyne cycloisomerization.
- Catalysts for cross-coupling.
Методы очистки
The palladium complex is recrystallised from EtOH. It should not be heated excessively as it dissociates to Pd(PPh3)3 and PdPh3 and then further to Pd(PPh3)2 and PPh3. It is also air sensitive as PPh3 is oxidized to PPh3O. It is stable only for short periods because on exposure to heat or air it turns from yellow to orange and dissociates in solution so the solutions should be used directly. However it can always be prepared freshly by mixing Pd(NO3)2 (2mmols) and PPh3(2mmols) in hot *C6H6 when vigorous evolution of nitric oxide occurs and a solid mass separates. This is collected and crystallised from EtOH. Its cryoscopic constant in *C6H6 (at 0.601g/20mL) corresponds to M 1156 [Malatesta & Angoletti J Chem Soc 1186 1957]. It is a useful catalyst for Suzuki coupling reactions [Trost Tetrahedron 33 2615 1977]. [Beilstein 16 IV 954.] This palladium catalyst bound to a polymer support (~0.06mmol/g) is also commercially available [cf Fenger & LeDrain Tetrahedron Lett 39 4287 1998]. [Beilstein 16 IV 954.]Тетракис (трифенилфосфин) палладий запасные части и сырье
сырьё
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запасной предмет
- 3-аминобифенил
- 3-(6-FORMYL-PYRIDIN-2-YL)-BENZONITRILE
- 6-(3-NITROPHENYL)-2-PYRIDINECARBOXALDEHYDE
- 6-(4-METHYLSULFANYLPHENYL)PYRIDINE-2-CARBALDEHYDE
- 6-(4-METHOXYPHENYL)PYRIDINE-2-CARBALDEHYDE
- Плумбагин
- 6-(THIOPHEN-3-YL)PYRIDINE-2-CARBALDEHYDE
- Димидиум бромид
- 3-AMINO-6-PHENYLPYRIDAZINE
- 4-PHENYLETHYNYLPHTHALIC ANHYDRIDE
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Тетракис (трифенилфосфин) палладий поставщик
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Тетракис (трифенилфосфин) палладий Обзор)
- Трифенилфосфин
- Тетракис(гидроксиметил)фосфин хлорид
- Тетраацетилэтилендиамин
- Цисплатин
- Дихлор [бис (diphenylphosphinophenyl) эфир] палладий (II)
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