Оротовая кислота

Химические свойства

white crystalline powder

Использование

Orotic acid is an intermediate in de novo pyrimidine biosynthesis that may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5?-phospho-α-d-ribose 1?-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5?-monophosphate (OMP). It is used as a starting material for the potential commercial bioproduction of uridine 5?-monophosphate (UMP) by microbes such as Corynebacterium ammoniagenes (ATCC 6872) or Saccharomyces cerevisiae. It may be used to study the AMPK/SREBP-1 dependent cell signaling pathway and transcription regulation mechanisms that induce hepatic lipogenesis.

Определение

ChEBI: A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.

Общее описание

White crystals or crystalline powder.

Реакции воздуха и воды

Slightly soluble in water.

Пожароопасность

Flash point data for Orotic acid are not available; however, Orotic acid is probably combustible.

Профиль безопасности

Moderately toxic by ingestion, intraperitoneal, and intravenous routes. Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx.