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Metalaxyl
- русский язык имя
- английское имяMetalaxyl
- CAS №57837-19-1
- CBNumberCB4431035
- ФормулаC15H21NO4
- мольный вес279.33
- EINECS260-979-7
- номер MDLMFCD00055447
- файл Mol57837-19-1.mol
Температура плавления | 72-73°C |
Температура кипения | 422.1°C (rough estimate) |
плотность | 1.1083 (rough estimate) |
давление пара | 7.5 x 10-4 Pa (25 °C) |
показатель преломления | 1.5130 (estimate) |
Fp | 100 °C |
температура хранения | Sealed in dry,2-8°C |
растворимость | Chloroform (Slightly), Methanol (Slightly) |
пка | 1.41±0.50(Predicted) |
форма | Solid |
цвет | Off-White to Pale Beige |
Растворимость в воде | 0.84 g/100 mL |
БРН | 2947777 |
Справочник по базе данных CAS | 57837-19-1(CAS DataBase Reference) |
Рейтинг продуктов питания EWG | 1-2 |
FDA UNII | 16K4M187IF |
Справочник по химии NIST | Dl-alanine, n-(2,6-dimethylphenyl)-n-(methoxyacetyl)-, methyl ester(57837-19-1) |
Пестициды Закон о свободе информации (FOIA) | Metalaxyl |
Система регистрации веществ EPA | Metalaxyl (57837-19-1) |
Коды опасности | Xn,F | |||||||||
Заявления о рисках | 22-43-52/53-36-20/21/22-11 | |||||||||
Заявления о безопасности | 13-24-37-46-61-36-26-16 | |||||||||
РИДАДР | UN 1648 3/PG 2 | |||||||||
WGK Германия | 2 | |||||||||
RTECS | AY6910000 | |||||||||
кода HS | 29242990 | |||||||||
Банк данных об опасных веществах | 57837-19-1(Hazardous Substances Data) | |||||||||
Токсичность | LD50 in rats (mg/kg): 669 orally (Urech) | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
предупреждение
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вредная бумага
H302:Вредно при проглатывании.
H317:При контакте с кожей может вызывать аллергическую реакцию.
H412:Вредно для водных организмов с долгосрочными последствиями.
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оператор предупредительных мер
P261:Избегать вдыхания пыли/ дыма/ газа/ тумана/ паров/ аэрозолей.
P264:После работы тщательно вымыть кожу.
P273:Избегать попадания в окружающую среду.
P280:Использовать перчатки/ средства защиты глаз/ лица.
P301+P312:ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии.
P302+P352:ПРИ ПОПАДАНИИ НА КОЖУ: Промыть большим количеством воды.
Metalaxyl химические свойства, назначение, производство
Описание
As an important fungicide group, acylanilides have a longer history than triazoles. Metalaxyl (44) is one of the most important fungicides in the group. It originates from the class of herbicidal chloroacetanilides, particularly metolachlor (45). Metolachlor, having a chiral carbon center and a chiral axis, is composed of four stereoisomers, the most herbicidally active one of which is the (αR, 1S)-isomer (32). For the stereoselective synthesis of this isomer, novel iridium-ferrocenyldiphosphine catalysts for the enantioselective hydrogenation of N-(2-ethyl-6-methylphenyl)- N-(1-methoxymethyl)-ethylidene-amine are reported. In the most effective approach, the catalyst is generated in situ from [Ir(cod)Cl]2(cod = cyclooctadiene) and the ferrocenyldiphosphine ligand (R)-(S)-PPF-P(3,5-xyl)2 (46) (33).When the substrate to catalyst ratio is 106, the conversion is complete in 2 to 3 h, producing metolachlor in optical yields over 80% (34).Химические свойства
Pale Beige SolidИспользование
Metalaxyl is used for the control of air-borne pathogens by foliar application and of soil-borne pathogens by soil application on a wide range of crops. It is particularly useful against Oomycetes including soil-borne Phytophthora diseases.Опасность
Moderately toxic by ingestion.Сельскохозяйственное использование
Fungicide: Metalaxyl is used as a systemic fungicide on a variety of food and non-food crops including tobacco, turf and conifers, and ornamentals. Used in combination with fungicides of different mode of action as a foliar spray on tropical and subtropical crops; as a seed treatment to control downy mildew; and as a soil fumigant to control soilborne pathogens.Торговое название
AGROX® PREMIERE; ALLEGIENCE®; APRON®; CG 117®; CGA-48988®; CHLORAXYL®; COTGUARD®; EPERON®; DELTA-COAT; FOLIO® GOLD; GAUCHO®; KODIAK®; METALAXIL®; METAXANIN®; PACE®; PREVAIL®; RAXIL® (tebu- conazole + metalaxyl); RIDOMIL® GOLD/BRAVO®; RIDOMIL®; RIDOMIL 2E®; SUBDUE®Фармаколо?гия
In mycelium of Phytophthora megasperma,metalaxyl affected primarily rRNA synthesis (polymerase I), whereas mRNA was much less sensitive; therefore, inhibition of rRNA synthesis is considered as the primary site of action of PAFs (23).The PAFs exhibit strong preventive and curative activity. They affect especially hyphal growth (inside and outside the plant tissue) as well as haustorium and spore formation (15). Although not fully utilized for resistance management reasons, PAFs also exhibit strong eradicative and antisporulant activity in the disease cycle of target pathogens. On the other hand, PAFs do not inhibit the early stages in the disease cycle like zoospore release, spore germination, and penetration of the host tissue (15). Because spores contain many ribosomes to support early growth stages, RNA synthesis is fully operating only after spore germination; later development stages are therefore most sensitive to PAFs (23). As a consequence of RNA inhibition, the precursors of RNA synthesis (i.e., nucleoside triphosphates) are accumulated; they activate β-1,3-glucansynthetases, which are involved in cell wall formation (23). Metalaxyl-treated hyphae often produce thicker cell walls than do untreated ones.
Профиль безопасности
Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx.Возможный контакт
Metalaxyl is phenylamide systemic fungicide used on a variety of food and nonfood crops including tobacco, turf and conifers, and ornamentals. Used in combination with fungicides of different mode of action as a foliar spray on tropical and subtropical crops; as a seed treatment to control downy mildew; and as a soil fumigant to control soil-borne pathogens. Banned for use in EU.Экологическая судьба
Soil. Little information is available on the degradation of metalaxyl in soil; however, Sharom and Edgington (1986) reported metalaxyl acid as a possible metabolite. Repeated applications of metalaxyl decreases its persistence. Following an initial application, the average half-life was 28 days. After repeated applications, the half-life decreased to 14 days (Bailey and Coffey, 1985).Carsel et al. (1986) studied the persistence of metalaxyl in various soil types. The application rate was 2.2 kg/ha. In a fine sand, metalaxyl concentrations at soil depths of 15, 20, 45 and 60 cm were 100, 150, 100 and 75 ppb, respectively, 55 days after
Plant. In plants, metalaxyl undergoes ring oxidation, methyl ester hydrolysis, ether cleavage, ring methyl hydroxylation and N-dealkylation (Owen and Donzel, 1986). Metalaxyl acid was identified as a hydrolysis product in both sunflower leaves an
In pigeon peas, metalaxyl may persist up to 12 days (Indira et al., 1981; Chaube et al., 1984).
Метаболический путь
O-Demethylation is one of the major routes of metalaxyl degradation in the plant cell suspension culture. Although hydroxylation of methyl groups in the phenyl ring predominates in both lettuce and grapes, species differences are evident in grapes, whereas N-dealkylation and aryl hydroxylation are less important in lettuce. Two isomeric metabolites of methyl hydroxylation and the hydroxylated metabolite of the phenyl ring are identified as fungus metabolites. By UV irradiation of metalaxyl in aqueous solution, two rearrangement products of the N-acyl group to the 4-position on the phenyl ring are identified.Перевозки
UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.Несовместимости
Incompatible with alkaline materials, strong acids, oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides (releasing heat, toxic, and possibly flammable gases), thiosulfates and dithionites (releasing hydrogen sulfate and oxides of sulfur).Утилизация отходов
Small amounts may be destroyed by alkaline hydrolysis. Admixture with alkali can be followed by soil burial. Larger quantities can be disposed of by incineration in admixture with acetone or xylene and using effluent gas scrubbing. Do not reuse empty container; proper disposal required.Metalaxyl запасные части и сырье
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Metalaxyl поставщик
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