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Целлюлоза микрокристаллы
- английское имяMicrocrystalline cellulose
- CAS №9004-34-6
- CBNumberCB4217972
- Формула(C12H20O10)n
- мольный вес324.28
- EINECS232-674-9
- номер MDLMFCD00081512
- файл Mol9004-34-6.mol
химическое свойство
Температура плавления | 76-78 °C(Solv: acetone (67-64-1); chloroform (67-66-3)) |
плотность | 1.5 g/cm3 (20℃) |
показатель преломления | n20/D 1.504 |
Fp | 164 °C |
температура хранения | room temp |
растворимость | Practically insoluble in water, in acetone, in anhydrous ethanol, in toluene, in dilute acids and in a 50 g/L solution of sodium hydroxide |
форма | powder |
цвет | White or almost white |
РН | 5-7.5 (100g/l, H2O, 20℃)(slurry) |
Запах | Odorless |
оптическая активность | -120 (Cuprammonium hydroxide solution) |
Растворимость в воде | insoluble |
Мерк | 14,1965 |
Пределы воздействия | ACGIH: TWA 10 mg/m3 OSHA: TWA 15 mg/m3; TWA 5 mg/m3 NIOSH: TWA 10 mg/m3; TWA 5 mg/m3; TWA 1 mg/m3 |
Диэлектрическая постоянная | 3.2(Ambient) |
Стабильность | Stable. Combustible. Incompatible with strong oxidizing agents. |
ИнЧИКей | UFHFLCQGNIYNRP-UHFFFAOYSA-N |
Непрямые добавки, используемые в веществах, контактирующих с пищевыми продуктами | CELLULOSE |
Специальный комитет по веществам GRAS | Cellulose |
Рейтинг продуктов питания EWG | 1 |
Словарь онкологических терминов NCI | cellulose |
FDA UNII | OP1R32D61U |
Система регистрации веществ EPA | Cellulose (9004-34-6) |
больше
Коды опасности | Xi | |||||||||
Заявления о рисках | 37 | |||||||||
Заявления о безопасности | 24/25 | |||||||||
OEB | B | |||||||||
OEL | TWA: 10 mg/m3 (total) | |||||||||
WGK Германия | 3 | |||||||||
RTECS | FJ5950200 | |||||||||
F | 3 | |||||||||
Температура самовоспламенения | 232 °C | |||||||||
TSCA | Yes | |||||||||
кода HS | 39129090 | |||||||||
Токсичность | LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 2000 mg/kg | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
-
рисовальное письмо(GHS)
-
вредная бумага
H335:Может вызывать раздражение верхних дыхательных путей.
-
оператор предупредительных мер
P261:Избегать вдыхания пыли/ дыма/ газа/ тумана/ паров/ аэрозолей.
P304+P340:ПРИ ВДЫХАНИИ: Свежий воздух, покой.
P403+P233:Хранить в хорошо вентилируемом месте в плотно закрытой/герметичной таре.
P405:Хранить в недоступном для посторонних месте.
Целлюлоза микрокристаллы химические свойства, назначение, производство
Химические свойства
Microcrystalline cellulose and carboxymethylcellulose sodium occurs as a white or off-white odorless and tasteless hygroscopic powder containing 5–22% sodium carboxymethylcellulose. It is a water-dispersible organic hydrocolloid.![Microcrystalline cellulose.jpg Microcrystalline cellulose.jpg](/NewsImg/2022-03-07/6378224819864415458497763.jpg)
Вхождение
The fiber in typical paper can be called “cellulosic”, meaning that cellulose is its most prominent component. Cellulose is present not only in wood, but also in various non-woody plants, such as straw, sugarcane (bagasse), reeds, and hemp.Использование
Microcrystalline Cellulose is a gum that is the nonfibrous form of cellulose, an alpha-cellulose. It is dispersible in water but not soluble, requiring considerable energy to disperse and hydrate. In this form it is used in dry applications such as tableting, capsules, and shredded cheese where it functions as a non-nutritive filler, binder, flow aid, and anticaking agent. By the addition of carboxymethylcellulose to the alpha-cellulose prior to drying, improved functional properties of hydration and dispersion are obtained. This product is designed for use in water dispersions, being insoluble in water but dispersing in water to form colloidal sols below 1% and white opaque gels above the 1% usage level. It is used as a heat shock stabilizer and bodying agent in frozen desserts, as an opacifier in low-fat dressings, as a foam stabilizer in whipped toppings, and as an emulsifier in dressings. Also termed cellulose gel.Определение
A natural carbohydrate high polymer (polysaccha- ride) consisting of anhydroglucose units joined by an oxygen linkage to form long molecular chains that are essentially linear. It can be hydrolyzed to glucose. The degree of polymerization is from 1000 for wood pulp to 3500 for cotton fiber, giving a molecular weight from 160,000 to 560,000. Cellulose is a colorless solid, d approximately 1.50, insoluble in water and organic solvents. It will swell in sodium hydroxide solution and is soluble in Schweitzer’s reagent. It is the fundamental con- stituent of all vegetable tissues (wood, grass, cotton, etc.) and the most abundant organic material in the world. Cotton fibers are almost pure cellulose; wood contains approximately 50%. The physical structure of cellulose is unusual in that it is not a single crystal but consists of crystalline areas embedded in amorphous areas. Chemical reagents penetrate the latter more easily than the former. Cel- lulose is virtually odorless and tasteless and is com- bustible, with an ignition point of approximately 450F. In some forms, it is flammable. For example, railroad shipping regulations require a flammable label on such items as burnt fiber, burnt cotton, wet waste paper, and wet textiles. Fires have been known to occur in warehouses in which telephone books were stored. These were undoubtedly due to heat buildup in the paper caused by microbial activity and self-sustaining oxidation.Методы производства
Microcrystalline cellulose and carboxymethylcellulose sodium is a spray- or bulk-dried blend of microcrystalline cellulose and sodium carboxymethylcellulose. It is prepared by the chemical depolymerization of highly purified wood pulp. The original crystalline areas of the pulp fibers are combined with sodium carboxymethylcellulose, which serves as a protective colloid and also facilitates dispersion of the product; it is then either spray- or bulk-dried.Общее описание
Odorless, white powdery fibers. Density 1.5 g cm-3. The biopolymer composing the cell wall of vegetable tissues. Prepared by treating cotton with an organic solvent to de-wax Cellulose microcrystalline and removing pectic acids by extration with a solution of sodium hydroxide. The principal fiber composing the cell wall of vegetable tissues (wood, cotton, flax, grass, etc.). Technical uses depend on the strength and flexibility of its fibers. Insoluble in water. Soluble with chemical degradation in sulfuric aicd, and in concentrated solutions of zinc chloride. Soluble in aqueous solutions of cupric ammonium hydroxide (Cu(NH3)4(OH)2).Профиль реактивности
Cellulose microcrystalline is combustible. Incompatible with strong oxidizing agents including bromine pentafluoride, sodium nitrate, fluorine, perchlorates, perchloric acid, sodium chlorate, magnesium perchlorate, F2, zinc permanganate, sodium nitrite, sodium nitrate, sodium peroxide. Nitration with a mixture of nitric and sulfuric acids produces Cellulose microcrystalline nitrates (celluloid pyroxylin, soluble pyroxyline, guncotton) which are flammable or explosive.Угроза здоровью
Cellulose is inert and is classified as a nuisance dust.It has little, if any, adverse effect on the lung, and there are no reports of organic disease or toxic effect. The health effects attributed to wood, cotton, flax, jute, and hemp are not attributable to their cellulose content but rather to the presence of other substances.
Cellulose fibers were found in the blood and urine of human volunteers fed dyed cellulose; there were no ill effects.
Фармацевтические приложения
Microcrystalline cellulose and carboxymethylcellulose sodium is used to produce thixotropic gels suitable as suspending vehicles in pharmaceutical and cosmetic formulations. The sodium carboxymethylcellulose aids dispersion and serves as a protective colloid.Concentrations of less than 1% solids produce fluid dispersions, while concentrations of more than 1.2% solids produce thixotropic gels. When properly dispersed, it imparts emulsion stability, opacity and suspension in a variety of products, and is used in nasal sprays, topical sprays and lotions, oral suspensions, emulsions, creams and gels.
Промышленное использование
Cellulose is the main constituent of the structureof plants (natural polymer) that, whenextracted, is employed for making paper,plastics, and in many combinations. Celluloseis made up of long-chain molecules inwhich the complex unit C6H10O5 is repeatedas many as 2000 times. It consists of glucose molecules with three hydroxyl groups foreach glucose unit.One of the simplest forms of cellulose usedindustrially is regenerated cellulose, in whichthe chemical composition of the finished productis similar to that of the original cellulose. Itis made from wood or cotton pulp digested ina caustic solution. Cellophane is a regeneratedcellulose in thin sheets for wrapping and otherspecial uses include windings on wire andcable.
Профиль безопасности
A nuisance dust. When heated to decomposition it emits acrid smoke and irritating fumes.Безопасность
Microcrystalline cellulose is widely used in oral pharmaceutical formulations and food products and is generally regarded as a relatively nontoxic and nonirritant material.Microcrystalline cellulose is not absorbed systemically following oral administration and thus has little toxic potential. Consumption of large quantities of cellulose may have a laxative effect, although this is unlikely to be a problem when cellulose is used as an excipient in pharmaceutical formulations.
Deliberate abuse of formulations containing cellulose, either by inhalation or by injection, has resulted in the formation of cellulose granulomas.
хранилище
Microcrystalline cellulose and carboxymethylcellulose sodium is hygroscopic and should not be exposed to moisture. It is stable over a pH range of 3.5–11. Store in a cool, dry place. Avoid exposure to excessive heat.Несовместимости
Microcrystalline cellulose is incompatible with strong oxidizing agents.Регуляторный статус
Microcrystalline cellulose and carboxymethylcellulose sodium is a mixture of two materials both of which are generally regarded as nontoxic:Microcrystalline cellulose GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (inhalations; oral capsules, powders, suspensions, syrups, and tablets; topical and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Carboxymethylcellulose sodium GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (dental preparations; intra-articular, intrabursal, intradermal, intralesional, and intrasynovial injections; oral drops, solutions, suspensions, syrups and tablets; topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.
Целлюлоза микрокристаллы запасные части и сырье
Целлюлоза микрокристаллы поставщик
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