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Метиленовый синий тригидра
- английское имяMethylene Blue trihydrate
- CAS №7220-79-3
- CBNumberCB3748860
- ФормулаC16H20ClN3OS
- мольный вес337.87
- EINECS615-731-6
- номер MDLMFCD00150008
- файл Mol7220-79-3.mol
химическое свойство
Температура плавления | 190 °C (dec.)(lit.) |
плотность | 0.98 g/mL at 25 °C |
Fp | 14 °C |
температура хранения | no restrictions. |
растворимость | Soluble in water, chloroform; sparingly soluble in ethanol |
Цветовой индекс | 52015 |
форма | Solid |
пка | 2.6, 11.2(at 25℃) |
цвет | Green |
Растворимость в воде | 4 g/100 mL |
λмакс | 668 nm, 609 nm |
Мерк | 13,6085 |
Стабильность | Stable. Incompatible with bases, reducing agents, strong oxidizing agents. |
Биологические приложения | Diagnosis of tauopathy,Alzheimer’s disease (AD),Pick’s disease; treating prophylaxis; dental materials |
ИнЧИКей | YAFGUSOAMIMROI-UHFFFAOYSA-M |
Справочник по базе данных CAS | 7220-79-3(CAS DataBase Reference) |
FDA UNII | T42P99266K |
МАИР | 3 (Vol. 108) 2016 |
Система регистрации веществ EPA | Methylene blue trihydrate (7220-79-3) |
больше
Коды опасности | Xn,F |
Заявления о рисках | 22-36/37/38-11 |
Заявления о безопасности | 26-36-24/25-16-7 |
РИДАДР | UN 1170 3/PG 2 |
WGK Германия | 3 |
RTECS | SP5740000 |
TSCA | Yes |
кода HS | 32129000 |
рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
предупреждение
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вредная бумага
H302:Вредно при проглатывании.
-
оператор предупредительных мер
P264:После работы тщательно вымыть кожу.
P270:При использовании продукции не курить, не пить, не принимать пищу.
P301+P312:ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии.
P501:Удалить содержимое/ контейнер на утвержденных станциях утилизации отходов.
Метиленовый синий тригидра химические свойства, назначение, производство
Химические свойства
Methylene Blue trihydrate is a dark green crystalline powder that has a bronze-like luster. When dissolved in water or alcohol, it creates a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It can also inhibit guanylate cyclase and has been used to treat cyanide poisoning and lower levels of methemoglobin.Использование
Methylene Blue trihydrate finds many uses in biology and chemistry. It acts as a GCS inhibitor, biological stain and redox indicator. It inhibits tau filament formation. Further, it is reported to bind to the M2 subtype of muscarinic receptors in rat cardiac myocytes and thus exhibit antimuscarinic effects on IK, ACh and ICa. It also inhibits endothelium-dependent relaxation of isolated blood vessels.Подготовка
Methylene blue is synthesized commercially by oxidation of N,N-dimethyl-phenylenediamine with sodium dichromate (Na2Cr2O7) in the presence of sodium thiosulfate (Na2S2O3), followed by further oxidation in the presence of N,N-dimethylaniline (NTP, 2008). Methylene blue hydrochloride is isolated by addition of 30% hydrochloric acid and of a saturated common salt solution to the dye solution; after filtration, the product is washed with a 2% common salt solution. Instead of sodium dichromate, manganese dioxide, and catalytic amounts of copper sulfate can be used for the oxidation (Berneth, 2008).Methylene blue of high purity can be obtained by chloroform extraction of impurities from solutions of raw dye in borate buffer at pH 9.5–10, followed by acidification of the aqueous solution and isolation of the dye (Berneth, 2008).
IARC Monographs
Общее описание
Methylene blue trihydrate appears as odorless or almost odorless dark green crystals with bronze luster or dark green crystalline powder. pH (1% solution in water) 3 to 4.5. (NTP, 1992)Реакции воздуха и воды
Hygroscopic. Water soluble. Gives a blue solution in water.Профиль реактивности
Methylene Blue trihydrate is incompatible with strong oxidizing agents, caustics, alkali metal iodides and reducing agents. Also incompatible with dichromates. Methylene Blue trihydrate forms double salts with many inorganic salts. Is bleached reversibly by (zinc + hydrochloric acid) or sodium hydrosulfite. In aqueous solution, Methylene Blue trihydrate is decolorized by zinc dust and dilute sulfuric acid, but the color is restored upon exposure to air and more rapidly upon addition of ammonium hydroxide.Пожароопасность
Flash point data for Methylene Blue trihydrate are not available; however, Methylene Blue trihydrate is probably combustible.Метиленовый синий тригидра запасные части и сырье
Метиленовый синий тригидра поставщик
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