(S)-Timolol maleate

Описание

Timolol is a non-selective β-adrenergic receptor antagonist with log K_d values of -8.27, -9.86, and -6.8 for binding to human β₁-, β₂-, and β₃-adrenoceptors, respectively. It has been reported that only the (S) enantiomer contributes to the β-blocking effects of racemic timolol, but the weakly active (R) isomer maintains a beneficial effect on intraocular pressure without the undesirable side-effect of bronchial constriction caused by non-selective action of (S)-timolol on β₁ and β₂ receptors. Timolol has been use alone and in fixed combinations with either prostaglandin analogs or carbonic anhydrase inhibitors to reduce intraocular pressure in research models of ocular hypertension and glaucoma.

Химические свойства

White Solid

Использование

betaadrenergic blocker

Определение

ChEBI: The maleic acid salt of the active (S)-enantiomer of timolol, comprising equimolar amounts of (S)-timolol and maleic acid.

Биологическая активность

β 1 -adrenergic blocker.