TOLUALDEHYDES

Химические свойства

Tolualdehydes, mixed o-, m-, p-, have a sweet and herbaceous odor reminiscent of bitter almond.

Вхождение

Reported found in roasted nuts, tomato, cooked beef, beef fat, cider, coffee, tea and elderberry juice.

Использование

Perfumes, pharmaceutical and dyestuff intermediate, flavoring agent.

Подготовка

By oxidation of o-, m-, or p-xylene (chemical or electrolytical oxidation).

Метаболизм

Aromatic aldehydes are oxidized in vivo almost entirely to the corresponding acid. Thus, in rabbits, p-tolualdehyde is converted to p-toluic acid which has been detected in the urine as the ester glucuronide (Williams, 1959). p-Tolualdehyde was oxidized to p-toluic acid by resting cells of Pseudomonas aeruginosa (Omori & Yamada, 1970). Perillaldehyde dehydrogenase, isolated from a soil pseudomonad, catalysed the oxidation of m- and p-tolualdehyde but not of o-tolualdehyde (Ballal, Bhattacharyya & Rangachari, 1967). The reduction of p-tolualdehyde by NADH was catalysed by horse-liver alcohol dehydrogenase (Blomquist, 1966) and by yeast alcohol dehydrogenase at pH 8.5-9.5 (Klinman, 1975). A non-specific NADPH-linked aldehyde reductase isolated from various areas of bovine brain also catalysed the reduction of p-tolualdehyde (Tabakoff & Erwin, 1970).