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Брефелдин A
- английское имяBrefeldin A
- CAS №20350-15-6
- CBNumberCB0689753
- ФормулаC16H24O4
- мольный вес280.36
- EINECS606-528-3
- номер MDLMFCD12913297
- файл Mol20350-15-6.mol
химическое свойство
Температура плавления | 200-205 °C |
Температура кипения | 492.7±45.0 °C(Predicted) |
альфа | 93 º (C=2 IN MEOH) |
плотность | 1.108±0.06 g/cm3(Predicted) |
давление пара | 0.56 hPa ( 20 °C) |
Fp | 87 °C |
температура хранения | Sealed in dry,Store in freezer, under -20°C |
растворимость | methanol: 10 mg/mL, clear, colorless to faintly yellow |
пка | 12.92±0.60(Predicted) |
форма | Crystalline Powder |
цвет | White to almost white |
Растворимость в воде | Soluble in dimethylsulfoxide, dichloromethane and ethanol. Slightly soluble in water. |
Мерк | 13,1355 |
БРН | 25191 |
Стабильность | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
ИнЧИКей | QSECOIOBNZLGOD-OBCVZTHZSA-N |
Справочник по базе данных CAS | 20350-15-6 |
FDA UNII | XG0D35F9K6 |
Коды опасности | Xn,T | |||||||||
Заявления о рисках | 22-25-36/37/38-20/21/22 | |||||||||
Заявления о безопасности | 24/25-45-36-26 | |||||||||
РИДАДР | UN 2811 6.1/PG 3 | |||||||||
WGK Германия | 3 | |||||||||
RTECS | GY8410000 | |||||||||
Температура самовоспламенения | 301 °C | |||||||||
кода HS | 29411090 | |||||||||
Токсичность | LD50 i.p. in mice: >200 mg/kg (Haerri) | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H301:Токсично при проглатывании.
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оператор предупредительных мер
P301+P310:ПРИ ПРОГЛАТЫВАНИИ: Немедленно обратиться за медицинской помощью. Прополоскать рот.
Брефелдин A химические свойства, назначение, производство
Химические свойства
White PowderИспользование
Brefeldin A is a potent inhibitor of cell growth first described in 1958, then independently rediscovered by several groups as a potent active in a broad range of bioassays. Brefeldin has antiviral, antibiotic, antifungal, antitumour and herbicidal activity. Early studies on the mode of action of brefeldin identified inhibition of protein and nucleic acid synthesis by disruption of the Golgi apparatus. The precise molecular target is a subset of Sec7-type GTP exchange factors (GEFs) that activate a small GTPase, Arf1p, an integral component of protein trafficking and signalling.Определение
ChEBI: A metabolite from Penicillium brefeldianum that exhibits a wide range of antibiotic activity.Общее описание
Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis or lysosome function. Inhibitor of HDL-mediated cholesterol efflux. Causes disassembly of the Golgi complex and ER swelling in a variety of mammalian cell lines at <40 ng/ml. Blocks binding of ADP-ribosylation factor to the Golgi and inhibits the GDP-GTP exchange. Inhibits the activity of BIG1 and BIG2, the guanine-nucleotide exchange proteins for ADP-ribosylation factors. Also available as a 25 mM solution in DMSO (Cat. No. 500583).Биологическая активность
Reversible inhibitor of protein translocation from the endoplasmic reticulum (ER) to the Golgi apparatus. Blocks binding of ADP-ribosylation factor to the Golgi apparatus and inhibits GDP-GTP exchange.Методы очистки
Brefeldin A was isolated from Penicillium brefeldianum and recrystallised from aqueous MeOH/EtOAc or MeOH. Its solubility in H2O is 0.6mg/mL, 10mg/mL in MeOH and 24.9mg/mL in EtOH. The O-acetate recrystallises from Et2O/pentane and has m 130-131o, [] D +17o (c 0.95, MeOH). [Sigg Helv Chim Acta 47 1401 1964, UV and IR: H.rri et al. Helv Chim Acta 46 1235 1963, total synthesis: Kitahara et al. Tetrahedron 3021 1979, X-ray : Weber et al. Helv Chim Acta 54 2763 1971, Beilstein 18 III/IV 1220.]Брефелдин A запасные части и сырье
сырьё
- 1-Hexanol, 5-(4-methoxyphenoxy)-, (5S)-
- 4H-Cyclopent[f]oxacyclotridecin-4-one, 1,6,7,8,9,11a,12,13,14,14a-decahydro-6-methyl-1,13-bis[(4-nitrobenzoyl)oxy]-, (1R,2E,6S,10E,11aS,13S,14aR)-
- 4H-Cyclopent[f]oxacyclotridecin-4-one, 1,13-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1,6,7,8,9,11a,12,13,14,14a-decahydro-6-methyl-, (1R,2E,6S,10E,11aS,13S,14aR)-
Брефелдин A поставщик
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