Chloramphenicol succinate sodium salt

Химические свойства

White or yellowish-white powder, hygroscopic

Использование

antibacterial, antirickettsial, inhibits protein synthesis

Общее описание

Chloramphenicol sodium succinate is the water-solublesodium salt of the hemisuccinate ester of chloramphenicol.Because of the low solubility of chloramphenicol, the sodiumsuccinate is preferred for intravenous administration. Theavailability of chloramphenicol from the ester followingintravenous administration is estimated to be 70% to 75%; theremainder is excreted unchanged. Poor availability ofthe active form from the ester following intramuscular injectionprecludes attaining effective plasma levels of the antibioticby this route. Orally administered chloramphenicol orits palmitate ester actually gives higher plasma levels of theactive antibiotic than does intravenously administered chloramphenicolsodium succinate. Nonetheless, effectiveconcentrations are achieved by either route.

Реакции воздуха и воды

Freely soluble in water.

Пожароопасность

Flash point data for Chloramphenicol sodium succinate are not available, but Chloramphenicol sodium succinate is probably combustible.