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Галофугинон
- английское имяHalofuginone
- CAS №55837-20-2
- CBNumberCB0361552
- ФормулаC16H17BrClN3O3
- мольный вес414.68
- EINECS1806241-263-5
- номер MDLMFCD09834143
- файл Mol55837-20-2.mol
химическое свойство
Температура плавления | >150°C dec. |
Температура кипения | 595.8±60.0 °C(Predicted) |
плотность | 1.73±0.1 g/cm3(Predicted) |
температура хранения | Keep in dark place,Sealed in dry,Room Temperature |
растворимость | DMSO : 9 mg/mL (21.70 mM) |
форма | Solid |
пка | 14.61±0.40(Predicted) |
цвет | White to off-white |
FDA 21 CFR | 556.308; 558.265 |
Справочник по базе данных CAS | 55837-20-2(CAS DataBase Reference) |
FDA UNII | L31MM1385E |
Галофугинон химические свойства, назначение, производство
Описание
Halofuginone hydrobromide (Halofuginone) is a specific collagen Type I inhibitor that antagonize or inhibit the development of new blood vessels, hence can prevent intimal hyperplasia at a vascular anastomosis. It is used in the treatment or prevention of coccidiosis in both humans and animals.Химические свойства
Off-White SolidИспользование
Halofuginone is a halogenated derivative of febrigugine. It is Used as an antiprotozoal.Биологическая активность
Halofuginone is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga. It has antimalarial and anticoccidial actions. In mammals, halofuginone at 10 ng/ml down-regulates Smad3, blocking TGF-β signaling and preventing both the differentiation of fibroblasts to myofibroblasts and the transitioning of epithelial cells to mesenchymal cells. Through this action, halofuginone blocks fibrosis and tumor progression in a variety of different models. This compound also competitively inhibits prolyl-tRNA synthetase (Ki = 18.3 nM), activating the amino acid starvation response. This prevents the differentiation of TH17 cells, blunting an autoimmune response.Галофугинон запасные части и сырье
Галофугинон поставщик
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