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![Кальцитриол структурированное изображение](/CAS/GIF/32222-06-3.gif)
Кальцитриол
- английское имяCalcitriol
- CAS №32222-06-3
- CBNumberCB0171027
- ФормулаC27H44O3
- мольный вес416.64
- EINECS250-963-8
- номер MDLMFCD00867079
- файл Mol32222-06-3.mol
Температура плавления | 119-1210C |
альфа | D25 +48° (methanol) |
Температура кипения | 474.91°C (rough estimate) |
плотность | 1.0362 (rough estimate) |
показатель преломления | 1.4700 (estimate) |
Fp | 14 °C |
температура хранения | 2-8°C |
пка | 14.43±0.40(Predicted) |
форма | Solid |
цвет | White to Almost white |
λмакс | 265nm(lit.) |
Мерк | 14,1644 |
БРН | 7559394 |
BCS Class | 2,4 |
Стабильность | Air and Light Sensitive |
ИнЧИКей | GMRQFYUYWCNGIN-UNVJKIGWSA-N |
Справочник по базе данных CAS | 32222-06-3(CAS DataBase Reference) |
Словарь онкологических терминов NCI | calcitriol |
FDA UNII | FXC9231JVH |
Словарь наркотиков NCI | calcitriol |
Код УВД | A11CC04,D05AX03 |
Коды опасности | T+,Xn,F | |||||||||
Заявления о рисках | 26/27/28-63-36/37/38-20/21/22-11 | |||||||||
Заявления о безопасности | 36/37/39-45-36-26-16-7 | |||||||||
РИДАДР | UN 2811 6.1/PG 1 | |||||||||
WGK Германия | 3 | |||||||||
RTECS | FZ4645000 | |||||||||
F | 8-10-19 | |||||||||
Класс опасности | 6.1(a) | |||||||||
Группа упаковки | I | |||||||||
кода HS | 29061900 | |||||||||
Банк данных об опасных веществах | 32222-06-3(Hazardous Substances Data) | |||||||||
Токсичность | mouse,LD50,intraperitoneal,1900ug/kg (1.9mg/kg),SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYEBEHAVIORAL: ATAXIA,Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 11, Pg. 4175, 1983. | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H372:Поражает органы в результате многократного или продолжительного воздействия.
H300+H310+H330:Смертельно при проглатывании, при контакте с кожей или при вдыхании.
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оператор предупредительных мер
P260:Не вдыхать газ/ пары/ пыль/ аэрозоли/ дым/ туман.
P262:Избегать попадания в глаза, на кожу или одежду.
P280:Использовать перчатки/ средства защиты глаз/ лица.
P302+P352+P310:ПРИ ПОПАДАНИИ НА КОЖУ: Промыть большим количеством воды. Немедленно обратиться за медицинской помощью.
P304+P340+P310:ПРИ ВДЫХАНИИ: Свежий воздух, покой. Немедленно обратиться за медицинской помощью.
P314:В случае плохого самочувствия обратиться к врачу.
Кальцитриол химические свойства, назначение, производство
Описание
Calcitriol is the active form of vitamin D and is also a kind of hormones in the body. It plays an important role in the regulation of calcium and phosphorus concentration. It can increase the blood calcium level by increasing the intestinal absorption of calcium and can also increase the release of the bone calcium release for increasing the blood calcium levels. This study was first conducted and reported by Michael F. Holick in 1971. The basic principle of action model of calcitriol in many cases is through binding with the vitamin D receptor (the VDR), e.g., the ligand-receptor complex forming between calcitriol and its receptor in the intestinal epithelial cells cytoplasm can be transferred to the nucleus for being as the transcriptional factor in promoting the expression of calcium-binding protein. The increased level of calcium-binding proteins can help the cell to actively transport of more calcium ions, thereby increasing the calcium absorption level. Calcium absorption while maintaining electrical neutrality also requires transporting anions, mainly the absorption of inorganic phosphate ions, so calcitriol also promote the absorption of phosphorus.Clinically, this drug can be used in the treatment of hypocalcemia, hypoparathyroidism (adult), osteomalacia, rickets (infants), chronic kidney disease, renal osteodystrophy, osteoporosis, as well as the prevention of glucocorticoid induced osteoporosis.
![Calcitriol-dimensional molecular structure](/NewsImg/2016-06-07/20166718302413474.jpg)
Calcitriol-dimensional molecular structure
The above information is edited by the chemicalbook of Dai Xiongfeng.
Химические свойства
White Crystalline PowderИспользование
Calcitriol (1α,25-dihydroxy Vitamin D3) is synthesized from 7-dehydrocholesterol in humans via a non-enzymatic photochemical reaction with 290-310 nm UV light in the skin. Hydroxylation of the resulting cholecalciferol in the liver produces 25-hydroxy Vitamin D3, the principal circulating form of Vitamin D. A second, tightly regulated hydroxylation in the kidney produces calcitriol. Plasma calcitriol levels range from 10-70 pg/ml and are influenced by numerous dietary and hormonal factors. The main physiologic effects of calcitriol are to increase the absorption of calcium at the level of the intestinal epithelium, and to increase the mineralization of bone via the direct stimulation of osteoblasts.[Cayman Chemical]Определение
ChEBI: Calcitriol is a hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol. It has a role as a bone density conservation agent, an antipsoriatic, an immunomodulator, an antineoplastic agent, a calcium channel modulator, a nutraceutical, a calcium channel agonist, a metabolite, a hormone, a human metabolite and a mouse metabolite. It is a hydroxycalciol, a member of D3 vitamins and a triol.Общее описание
1α,25-Dihydroxyvitamin D3, also referred as calcitriol, is a calcitrophic hormone. It is the most biologically active metabolite of vitamin D produced in proximal tubular cells in the kidney.Биологическая активность
Active metabolite of vitamin D 3 that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca 2+ absorption and regulates bone Ca 2+ turnover. Exhibits antitumor activity; inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.Кальцитриол запасные части и сырье
сырьё
запасной предмет
Кальцитриол поставщик
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