Убидекаренон

Химические свойства

Yellow-Orange Crystalline Powder

Вхождение

Coenzyme Q10 is found in dietary sources. Coenzyme Qmolecules have side chains of differentlengths in different types of organismsbut function in similar ways.

Использование

Ubidecarenone is also known as coenzyme Q10 it is a powerful antioxidant that is naturally found in the cells. It acts as a free radical neutraliser.

Определение

ChEBI: Coenzyme Q10 is a ubiquinone having a side chain of 10 isoprenoid units. In the naturally occurring isomer, all isoprenyl double bonds are in the E- configuration. It has a role as a human metabolite, a ferroptosis inhibitor and an antioxidant. It is found in animal organs and yeast with active in the citric acid cycle in carbohydrate metabolism.

Общее описание

Ubidecarenone, referred to as coenzyme Q, is abundantly available in human cells, with major proportions being present in vital body organs such as heart and kidneys. It plays an important role in cell metabolism owing to its significant contribution to the electron transport pathway. It is a strong antioxidant and acts as an essential enzyme catalyst in mitochondrial oxidative phosphorylation.

Биологическая активность

Component of the mitochondrial transporter chain that behaves as a powerful antioxidant. Displays neuroprotective activity.

Побочные эффекты

Mild side effects might include digestive problems such as: Upper abdominal pain; Loss of appetite; Nausea and vomiting; Diarrhea.
Other possible side effects may include: Headaches and dizziness; Insomnia; Fatigue; Skin itching or rashes; Irritability or agitation.

Методы очистки

Purify it by recrystallisation from EtOH, EtOH/Me2CO or Et2O/EtOH and by chromatography on silica gel using isoPrOH/Et2O (3:1) to give orange crystals. It has max 270nm ( 15,170) in pet ether. [Terao et al. J Org Chem 44 868 1979, NMR and MS: Naruta et al. J Org Chem 45 4097 1980, IR: Lester et al. Biochem Biophys Acta 42 1278 1959, NMR: Planta et al. Helv Chim Acta 42 1278 1959; Morton Biochemical Spectroscopy (Adam Hilger, London, 1975) p 491].