MS1943 (150 mg/kg body weight; i.p.; once daily for 36 days) suppresses tumor growth[1].
MS1943 induces apoptosis in the MDA-MB-468 xenograft model[1].
A single i.p. injection of MS1943 at 50 mg/kg body weight achieved a peak plasma concentration (Cmax) of 2.9 μM and resulted in plasma concentrations above its cellular IC50 value for ~2h. A single 150 mg/kg body weight p.o. dose achieved Cmax of 1.1 μM, but plasma concentrations were below the cellular IC50 value[1].
| Animal Model: | Eight-week-old female BALB/c nude mice (MDA-MB-468 xenografts)[1] |
| Dosage: | 150 mg/kg body weight |
| Administration: | i.p.; once daily for 36 days |
| Result: | Suppresses tumor growth. |
